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Alterations in Hepatic Gene Expressions of CYP2C11, CYP2C6V, and CYP2D3 Enzymes in Endotoxemic Rats

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dc.creator Kurtgoz, Serkan
dc.creator Ozer, Erdem K.
dc.creator Goktas, Mustafa T.
dc.creator Karaca, Ragip O.
dc.creator Caliskan, Metin
dc.creator Bariskaner, Hulagu
dc.creator Iskit, Alper B.
dc.date 2017-08-01T00:00:00Z
dc.date.accessioned 2021-12-03T11:54:24Z
dc.date.available 2021-12-03T11:54:24Z
dc.identifier bc770f0d-d50a-4423-ba4e-a83d1efb4c66
dc.identifier 10.5152/dcbybd.2017.1552
dc.identifier https://avesis.sdu.edu.tr/publication/details/bc770f0d-d50a-4423-ba4e-a83d1efb4c66/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/94573
dc.description Objective: Human cytochrome P450 2C9 (CYP2C9), CYP2C19, and CYP2D6 (corresponding to rat CYP2C11, CYP2C6V, and CYP2D3, respectively) are the major enzymes responsible for the metabolism of a wide range of drugs and chemicals. Changes in CYP efficiency are associated with disease susceptibility that can lead to drug toxicity or ineffective therapy. We aimed to examine the effects of lipopolysaccharide (LPS)-induced endotoxemia on gene expressions of hepatic microsomal CYP enzymes in rats.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title Alterations in Hepatic Gene Expressions of CYP2C11, CYP2C6V, and CYP2D3 Enzymes in Endotoxemic Rats
dc.type info:eu-repo/semantics/article


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