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Immunohistochemical expression of MMP-2, MMP-9 and COX-2 in Stage IA malignant polyps of the endometrium

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dc.creator Guney, M.
dc.creator Mungan, T.
dc.creator Karahan, N.
dc.creator Erdemoglu, E.
dc.date 2008-01-01T01:00:00Z
dc.date.accessioned 2021-12-03T11:54:56Z
dc.date.available 2021-12-03T11:54:56Z
dc.identifier c61c291f-fc56-4482-ae30-db31fee04878
dc.identifier https://avesis.sdu.edu.tr/publication/details/c61c291f-fc56-4482-ae30-db31fee04878/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/94780
dc.description Objective: To study whether endometrioid type malignant endometrial polyps (MEP) are different from endometrium cancer not associated with polyps (ECNAP) in means of immunohistochemical expressions of MMP-2. MMP-9 and COX-2. Methods: Archived tissue samples of eight MER eight ECNAP and 16 benign endometrial polyps were selected and immunohistochemically analyzed for MMP-2, MMP-9 and COX-2 expression. Results: MMP-2 and MMP-9 were overexpressed in ECNAP compared to MEP and benign endometrial polyps (p < 0.05). MMP-2 and MMP-9 expressions were not different in the malignant part of MEP, benign part of MEP and benign endometrial polyps. COX-2 expression was found to be higher in benign lesions, although this was not statistically significant. Conclusion: Similar immunohistochemical expression of MMP-2. MMP-9 and COX-2 within a polyp and with benign polyps may indicate an immunohistochemically indolent characteristic of MEP.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title Immunohistochemical expression of MMP-2, MMP-9 and COX-2 in Stage IA malignant polyps of the endometrium
dc.type info:eu-repo/semantics/article


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