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Optimization strategy for isocratic separation of alpha-aspartame and its breakdown products by reversed phase liquid chromatography

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dc.creator Demiralay, EC
dc.creator Ozkan, G
dc.date 2004-11-01T01:00:00Z
dc.date.accessioned 2021-12-03T12:02:41Z
dc.date.available 2021-12-03T12:02:41Z
dc.identifier cb9c5306-62b7-49aa-a293-ce3eba385eae
dc.identifier 10.1365/s10337-004-0421-7
dc.identifier https://avesis.sdu.edu.tr/publication/details/cb9c5306-62b7-49aa-a293-ce3eba385eae/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/94900
dc.description alpha-Aspartame (L-alpha-aspartyl-L-phenylalanine methyl ester) is increasingly being used in wide variety of commonly consumed food products. This structure contains ester and peptide bonds. The ester linkage may hydrolyze to produce L-alpha-aspartyl-L-phenylalanine or cyclohydrolyze to produce the corresponding cliketopiperazine ring. This ring can open to form L-alpha-aspartyl-Lphenylalanine and ultimately this compound can hydrolyze to L-phenylalanine and L-aspartic acid. The pH, buffer type, concentration, the presence of water and temperature are other important factors affecting its stability. Because a-aspartame can lose its sweetness under these conditions determination of aspartame and its breakdown products is extremely important for diet foods quality.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title Optimization strategy for isocratic separation of alpha-aspartame and its breakdown products by reversed phase liquid chromatography
dc.type info:eu-repo/semantics/article


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