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Clinical and epidemiological features of Turkish children with 2009 pandemic influenza A (H1N1) infection: Experience from multiple tertiary paediatric centres in Turkey

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dc.creator Dalgic, Nazan
dc.creator Dogru, Ulker
dc.creator ELHAN, ATİLLA HALİL
dc.creator Zohre, Seray Umut
dc.creator Kilinc, Ayse Ayzit
dc.creator Altindag, Hakan
dc.creator Unal, Nurettin
dc.creator Fisgin, Tunc
dc.creator Yakut, Halil Ibrahim
dc.creator Kendirli, Tanil
dc.creator Bucak, Ibrahim Hakan
dc.creator CEYHAN, MEHMET
dc.creator Dizdarer, Ceyhun
dc.creator Asilioglu, Nazik
dc.creator Ozaydin, Eda
dc.creator Kuzdan, Canan
dc.creator Ozgur, Ozlem
dc.creator Anil, Murat
dc.creator Hacimustafaoglu, Mustafa
dc.creator İNCE, ERDAL
dc.creator DERİNÖZ, OKŞAN
dc.creator Canoz, Perihan Yasemen
dc.creator CENGİZ, ALİ BÜLENT
dc.creator Aytac, Didem Buyuktas
dc.creator Evren, Gultac
dc.creator Belet, Nursen
dc.creator Celikel, Elif
dc.creator Tanir, Gonul
dc.creator KUYUCU, NECDET
dc.creator Soysal, Ahmet
dc.creator Ozen, Metehan
dc.creator DİNLEYİCİ, ENER ÇAĞRI
dc.creator KOCABAŞ, EMİNE
dc.creator Bayram, Nuri
dc.creator ÇELEBİ, SOLMAZ
dc.creator Keser, Melike
dc.creator TAPISIZ, ANIL
dc.creator Turgut, Mehmet
dc.creator KARA, ATEŞ
dc.creator Devrim, Ilker
dc.creator Sensoy, Gulnar
dc.creator Tezer, Hasan
dc.creator ÖZDEMİR, HALİL
dc.creator Tuygun, Nilden
dc.creator ÇİFTCİ, ERGİN
dc.date 2011-12-01T01:00:00Z
dc.date.accessioned 2021-12-03T12:02:55Z
dc.date.available 2021-12-03T12:02:55Z
dc.identifier cf9b10f3-ada9-4361-9119-498c5ff5fabc
dc.identifier 10.3109/00365548.2011.598872
dc.identifier https://avesis.sdu.edu.tr/publication/details/cf9b10f3-ada9-4361-9119-498c5ff5fabc/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/94991
dc.description Background: In April 2009 a novel strain of human influenza A, identified as H1N1 virus, rapidly spread worldwide, and in early June 2009 the World Health Organization raised the pandemic alert level to phase 6. Herein we present the largest series of children who were hospitalized due to pandemic H1N1 infection in Turkey. Methods: We conducted a retrospective multicentre analysis of case records involving children hospitalized with influenza-like illness, in whom 2009 H1N1 influenza was diagnosed by reverse-transcriptase polymerase chain reaction assay, at 17 different tertiary hospitals. Results: A total of 821 children with 2009 pandemic H1N1 were hospitalized. The majority of admitted children (56.9%) were younger than 5 y of age. Three hundred and seventy-six children (45.8%) had 1 or more pre-existing conditions. Respiratory complications including wheezing, pneumonia, pneumothorax, pneumomediastinum, and hypoxemia were seen in 272 (33.2%) children. Ninety of the patients (11.0%) were admitted or transferred to the paediatric intensive care units (PICU) and 52 (6.3%) received mechanical ventilation. Thirty-five children (4.3%) died. The mortality rate did not differ between age groups. Of the patients who died, 25.7% were healthy before the H1N1 virus infection. However, the death rate was significantly higher in patients with malignancy, chronic neurological disease, immunosuppressive therapy, at least 1 pre-existing condition, and respiratory complications. The most common causes of mortality were pneumonia and sepsis. Conclusions: In Turkey, 2009 H1N1 infection caused high mortality and PICU admission due to severe respiratory illness and complications, especially in children with an underlying condition.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title Clinical and epidemiological features of Turkish children with 2009 pandemic influenza A (H1N1) infection: Experience from multiple tertiary paediatric centres in Turkey
dc.type info:eu-repo/semantics/article


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