| dc.creator |
Sezik, E. |
|
| dc.creator |
Sezik, Mekin |
|
| dc.creator |
Aslan, M. |
|
| dc.creator |
Erdemoglu, E. |
|
| dc.creator |
Pekcan, M. |
|
| dc.creator |
Mungan, T. |
|
| dc.creator |
Orhan, D. D. |
|
| dc.date |
2010-02-01T01:00:00Z |
|
| dc.date.accessioned |
2021-12-03T12:04:47Z |
|
| dc.date.available |
2021-12-03T12:04:47Z |
|
| dc.identifier |
ee7671ee-d510-4196-963b-71f0b42f0911 |
|
| dc.identifier |
10.3109/01443610903474348 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/ee7671ee-d510-4196-963b-71f0b42f0911/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/95707 |
|
| dc.description |
Our aim was to investigate the hypoglycaemic and antioxidant effects of the Helichrysum plicatum ssp. plicatum (HPsP) plant extract in the streptozotocin-induced type 1 diabetes rat model during pregnancy. Five groups (n = 8, each) were formed: (1) diabetic non-mated control, (2) non-diabetic mated control, (3) diabetic mated control, (4) diabetic non-mated treatment and (5) diabetic mated treatment. The HPsP extract was administered orally for 15 days (250 mg/kg body weight), beginning 3 days before mating. The extract led to decreased blood glucose, increased serum insulin, and decreased serum triglycerides in pregnant and non-pregnant diabetic animals. Liver thiobarbituric acid reactive substances (TBARS) and reduced glutathione (GSH) measurements in extract-treated diabetics were similar to non-diabetic pregnant controls, indicating probable reversal of increased lipid peroxidation in the liver. The mean pup number tended to increase (p = 0.06) with extract administration. In conclusion, the beneficial effects we encountered with the periconception use of the studied herbal extract warrant further investigation.</. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Improved metabolic control and hepatic oxidative biomarkers with the periconception use of Helichrysum plicatum ssp. plicatum. |
|
| dc.type |
info:eu-repo/semantics/article |
|