| dc.creator |
YILMAZER, MEHMET |
|
| dc.creator |
Tokyol, Cigdem |
|
| dc.creator |
Ozdemir, Oner |
|
| dc.creator |
ARIÖZ, DAĞISTAN TOLGA |
|
| dc.creator |
Erol, Y. Azize Goksu |
|
| dc.creator |
Aktepe, Fatma |
|
| dc.date |
2012-02-01T01:00:00Z |
|
| dc.date.accessioned |
2021-12-03T12:05:15Z |
|
| dc.date.available |
2021-12-03T12:05:15Z |
|
| dc.identifier |
f5db5d3f-2db3-46f9-9084-22f0a27a476a |
|
| dc.identifier |
10.5336/medsci.2010-22258 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/f5db5d3f-2db3-46f9-9084-22f0a27a476a/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/95866 |
|
| dc.description |
Objective: Angiogenesis is a major factor in the development of solid tumors, such as endometrial cancer. Vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) are important cytokines that stimulate angiogenesis in vivo. The aim of the current study was to determine VEGF and COX-2 expression in endometrial adenocarcinomas and to investigate the relationship between these parameters and clinicopathologic parameters. Material and Methods: Sections obtained from paraffin-embedded tissues in archive material of 23 patients who were diagnosed with endometrial carcinoma were retrospectively evaluated. VEGF and COX-2 expression levels in tumor cells and surrounding stroma on the tumor samples were determined by immunohistochemistry. Results: VEGF and COX-2 were expressed both in the cytoplasm of tumor cells and in the stromal cells, but in a lower degree. There was a significant positive correlation between VEGF expressions of cancer cells and the stroma (r=0.705, p<0.01). A negative correlation was found between histological grade of the tumor and VEGF expression of cancer cells (r=-0.622, p=0.002). A negative correlation was determined between myometrial invasion of the tumor and COX-2 expression of cancer cells (r=-0.441, p=0.035). Conclusion: Both VEGF and COX-2 were expressed by both tumor cells and stromal cells in endometrial cancer. While VEGF expression showed a negative correlation with the tumor grade, COX-2 expression exhibited a negative correlation with the myometrial invasion of the tumor. No correlation was determined between their expressions and other clinicopathologic prognostic parameters. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
VEGF and COX-2 Expression in Endometrial Carcinoma |
|
| dc.type |
info:eu-repo/semantics/article |
|