DSpace Repository

Genetic polymorphisms of paraoxonase1 192 and glutathione peroxidase1 197 enzymes in familial Mediterranean fever

Show simple item record

dc.creator Kuybulu, A. E.
dc.creator Anil, H.
dc.creator Sutcu, R.
dc.creator Oktem, F.
dc.date 2014-01-01T01:00:00Z
dc.date.accessioned 2021-12-03T12:05:27Z
dc.date.available 2021-12-03T12:05:27Z
dc.identifier f97f3e9a-5171-4cab-ba1f-53d40f436dd9
dc.identifier 10.4238/2014.april.29.7
dc.identifier https://avesis.sdu.edu.tr/publication/details/f97f3e9a-5171-4cab-ba1f-53d40f436dd9/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/95942
dc.description Familial Mediterranean fever (FMF) is an autosomal recessive disorder and is the most frequent of the periodic febrile inflammatory syndromes. The pathogenesis of the disease is not completely understood, even though the FMF gene has been identified. Oxidative stress and inflammation may play a role in the pathogenesis of FMF. We investigated gene polymorphisms of the antioxidative enzymes, glutathione peroxidase (GPX) and paraoxonase (PON) in FMF patients, and possible associations with FMF pathogenesis. Sixty FMF patients during an attack-free period and 51 healthy children as the control group were included in our study. PON1 Q/R192 and GPX1 Pro197Leu gene polymorphisms were assayed. Blood urea nitrogen, creatinine and serum lipid profile were also measured. PON1 Q/R192 genotype distribution was 52% QQ, 46% QR and 2% RR in the FMF group and 45% QQ, 45% QR and 10% RR in the control group (P > 0.05). GPX1 Pro197Leu genotype distribution was 28% PP, 57% PL, 15% LL in the FMF group and 18% PP, 53% PL, 29% LL in the control group (P > 0.05). Blood urea nitrogen, serum creatinine, lipid levels, and the distribution of PON1 Q/R192 and GPX1 Pro197Leu genotypes were similar in the two groups. We conclude that the PON1 Q/R192 and GPX1 Pro197Leu gene polymorphisms are not important risk factors in the development of FMF. However, larger studies are warranted to validate these conclusions.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title Genetic polymorphisms of paraoxonase1 192 and glutathione peroxidase1 197 enzymes in familial Mediterranean fever
dc.type info:eu-repo/semantics/article


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account