| dc.creator |
ESKİTOROS TOĞAY, Şükran Melda; TÜRKİYE İLAÇ VE TIBBİ CİHAZ KURUMU BAŞKANLIĞI |
|
| dc.creator |
TOKGOZ, Ulya; GAZI UNIVERSITY, FACULTY OF ENGINEERING, DEPARTMENT OF CHEMISTRY ENGINEERING |
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| dc.date |
2022-03-01T00:00:00Z |
|
| dc.date.accessioned |
2022-05-10T10:58:57Z |
|
| dc.date.available |
2022-05-10T10:58:57Z |
|
| dc.identifier |
https://dergipark.org.tr/tr/pub/sdutfd/issue/68474/1016353 |
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| dc.identifier |
10.17343/sdutfd.1016353 |
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| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/96221 |
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| dc.description |
AmaçBu çalışmanın amacı, poli(laktik asit) matrisi içerisindemodifiye edilmemiş ve modifiye edilmiş nanopartikülleriçeren nanokompozit filmleri sentezlemek, karakterizeetmek ve doku mühendisliğinde alternatif biryapı iskelesi olarak kullanımlarını araştırmaktır.Gereç ve Yöntemİlk olarak, titanyum dioksit (TiO2) nanopartikülleri sırasıylaL-laktik asit oligomeri (LA-g-TiO2) ve propiyonikasit/heksilamin (AA-g-TiO2) karışımı ile aşılanmıştır.Daha sonra, PLA/TiO2, PLA/LA-g-TiO2 ve PLA/AAg-TiO2 nanokompozit filmleri üretmek için modifiyeedilmemiş ve modifiye edilmiş nanopartiküller solventdöküm yöntemi ile poli (laktik asit) matrisi içine eklenmiştir.Sentezlenen bu filmlerin kimyasal, termal vemekanik yapıları daha sonra karakterize edilmiştir.BulgularAzaltılmış toplam yansıma (ATR) sonuçları, nanopartiküllerinyüzey modifikasyonunun başarılı olduğunugöstermiştir. Diferansiyel tarama kalorimetresi (DSC)analizinin sonuçları, modifiye edilmiş nanopartiküllerindahil edilmesiyle PLA’nın kristalleşmesinin kısmenarttığını göstermiştir. Termogravimetrik analizin(TGA) sonuçları, polimer matrisine LA-g-TiO2 eklenmesinin,PLA/LA-g-TiO2 nanokompozit filmin termalstabilitesini, polimer matrisine AA-g-TiO2 ilavesindendaha fazla geliştirdiğini göstermiştir. LA-g-TiO2 içerennanokompozitlerin birinci ve ikinci bozunma sıcaklıklarısırasıyla 348.3 oC ve 392 oC, saf PLA’nınkinden%6 daha yüksektir. Nanokompozitlerin atomik kuvvetmikroskobu (AFM) mikrografı, LA-g-TiO2 ve AAg-TiO2 nanopartiküllerin polimer matrislerde homojenolarak dağıldığını göstermiştir. Dinamik mekanik analiz(DMA) sonuçları, diğer nanokompozitlere kıyaslaPLA/LA-g-TiO2 nanokompozitinde en verimli bağlanmave uyumluluğun elde edildiğini göstermiştir.SonuçAşılanmış nanopartiküller, LA-g-TiO2 ve AA-g-TiO2,matris içindeki homojen dağılımları ve polimerik matrisile iyi etkileşimleri sayesinde nanokompozitlerintermal ve mekanik özelliklerini iyileştirmiştir. Bu nedenle,bu nanokompozitler kemik doku mühendisliğindealternatif doku iskeleleri olarak kullanılabilir |
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| dc.description |
ObjectiveThis study aims to synthesize and characterize thenanocomposite films incorporating unmodified andmodified nanoparticles within the poly(lactic acid)matrix, and to investigate their usage as an alternativescaffold for tissue engineering.Materials and MethodsTitanium dioxide (TiO2) nanoparticles were firstlygrafted by L-lactic acid oligomer (LA-g-TiO2) and themixture of propionic acid/hexylamine (AA-g-TiO2),respectively. Then the unmodified and modifiednanoparticles were incorporated within the poly(lacticacid) matrix via the solvent casting method to producethe PLA/TiO2, PLA/LA-g-TiO2, and PLA/AA-g-TiO2nanocomposite films. The chemical, thermal andmechanical structures of these synthesized films weresubsequently characterized.ResultsThe attenuated total reflectance (ATR) resultsdemonstrated that the surface modification of thenanoparticles was accomplished. The results ofdifferential scanning calorimeter (DSC) analysisshowed that the crystallization of the PLA waspartly increased by the incorporation of modifiednanoparticles. The results of thermogravimetricanalysis (TGA) showed that the addition of LA-g-TiO2into the polymer matrix improved the thermal stabilityof PLA/LA-g-TiO2 nanocomposite film more than theaddition of AA-g-TiO2 into the polymer matrix. Thefirst and second decomposition temperatures of thenanocomposites containing LA-g-TiO2 were 348.3 oCand 392 oC, respectively, which were 6% greater thanthose of the neat PLA. The micrograph of atomic forcemicroscopy (AFM) of the nanocomposites indicatedthat LA-g-TiO2 and AA-g-TiO2 were homogeneouslydispersed in polymer matrices. The results of dynamicmechanical analysis (DMA) demonstrated that themost efficient bonding and compatibility were obtainedin PLA/LA-g-TiO2 nanocomposite compared to theother nanocomposites.ConclusionThese grafted nanoparticles, LA-g-TiO2 and AA-g-TiO2, enhanced the thermal and mechanical propertiesof the nanocomposites owing to their uniformdistribution in the matrix and good interactions with thepolymeric matrix. Therefore, these nanocompositescan be utilized as alternative scaffolds in bone tissueengineering. |
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| dc.format |
application/pdf |
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| dc.language |
en |
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| dc.publisher |
Süleyman Demirel Üniversitesi |
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| dc.publisher |
Süleyman Demirel University |
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| dc.relation |
https://dergipark.org.tr/tr/download/article-file/2053006 |
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| dc.source |
Volume: 29, Issue: 1
111-120 |
en-US |
| dc.source |
1300-7416 |
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| dc.source |
2602-2109 |
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| dc.source |
SDÜ Tıp Fakültesi Dergisi |
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| dc.subject |
Poli(laktik asit),yüzeyi modifiye edilmiş titanium dioksit,aşılama,nanokomposit,nanopartikül,doku mühendisliği |
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| dc.subject |
Poly(lactic acid),surface modified titanium dioxide,grafted,nanocomposite,nanoparticles,tissue engineering |
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| dc.title |
DOKU MÜHENDİSLİĞİ İÇİN YÜZEYİ MODİFİYE EDİLMİŞ TİTANYUM DİOKSİT/POLİ (LAKTİK ASİT) NANOKOMPOZİT FİLMLER |
tr-TR |
| dc.title |
SURFACE MODIFIED TITANIUM DIOXIDE/POLY (LACTIC ACID) NANOCOMPOSITE FILMS FOR TISSUE ENGINEERING |
en-US |
| dc.type |
info:eu-repo/semantics/article |
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