| dc.creator |
Hakan, Kurt Akif |
|
| dc.creator |
Derya, Kilicaslan |
|
| dc.creator |
Ebru, Uras |
|
| dc.creator |
Adem, Doganer |
|
| dc.creator |
Bilge, Alli |
|
| dc.date |
2021-11-01T00:00:00Z |
|
| dc.date.accessioned |
2022-05-10T11:17:04Z |
|
| dc.date.available |
2022-05-10T11:17:04Z |
|
| dc.identifier |
3db5796d-bbc8-4b67-966f-fbf52843f681 |
|
| dc.identifier |
10.1007/s11094-021-02490-1 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/3db5796d-bbc8-4b67-966f-fbf52843f681/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/96574 |
|
| dc.description |
This study was aimed to determine the efficacy of 6-hydroxy melatonin and N-acetyl serotoninin protecting human retinal pigment epithelial cells from death brought about by oxidative-stress. The ARPE-19 cells (one of the retinal pigment epithelial cell lines) were used as the test cell culture. Following the application of 500 mu M H2O2, ARPE-19 cell line culture was incubated for 20 h to induce oxidative stress damage. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide) assay was used to evaluate the oxidative injury to ARPE-19 cells caused by H2O2 and the effectiveness of 6-hydroxy melatonin and N-acetyl serotonin application in preventing this damage. The results indicated that 6-hydroxy melatonin and N-acetyl serotonin exhibited a therapeutic effect on cells damaged by exposure to oxidative stress. It was concluded that these melatonin metabolites might be useful in treating many retinal conditions linked to the oxidative stress-induced damage. In addition, this study proposed a new idea for developing chemical approaches to the design and synthesis/semisynthesis of new drugs. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Melatonin Metabolites Protect Human Retinal Pigment Epithelial Cells from Death Caused by Oxidative Stress |
|
| dc.type |
info:eu-repo/semantics/article |
|