| dc.creator |
ÖZMEN, ÖZLEM |
|
| dc.creator |
Yigit, Umut |
|
| dc.creator |
KIRZIOĞLU, Fatma Yeşim |
|
| dc.date |
2022-02-01T00:00:00Z |
|
| dc.date.accessioned |
2022-05-10T11:18:39Z |
|
| dc.date.available |
2022-05-10T11:18:39Z |
|
| dc.identifier |
63fa74ea-bfd8-458e-af14-34684b138d30 |
|
| dc.identifier |
10.1080/10520295.2022.2036370 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/63fa74ea-bfd8-458e-af14-34684b138d30/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/96672 |
|
| dc.description |
We investigated the effects of caffeic acid phenethyl ester (CAPE) and low-dose doxycycline (LDD) on sclerostin and bone morphogenic protein (BMP)-2 expression in experimental periodontitis. We used male rats in groups as follows: control group (C), periodontitis + CAPE group (PC), periodontitis + LDD group (PD), periodontitis + LDD + CAPE group (PCD) and periodontitis group (P). We administered 10 mu mol/kg/day CAPE by an intraperitoneal (i.p.) injection and 10 mg/kg/day LDD by oral gavage. Histopathological changes among groups were evaluated and compared. Sclerostin and BMP-2 expression was analyzed using immunohistochemistry. LDD and/or CAPE treatment ameliorated pathology. The highest sclerostin and lowest BMP-2 expressions were found in P group. Group PC exhibited the highest BMP-2 expression scores and the most significant improvement among the treatment groups. The lowest sclerostin expression was observed in the PD group. We found that preventing sclerostin activity may be a useful treatment alternative for bone resorption, especially in cases of periodontitis and peri-implantitis. We found that CAPE and/or LDD may act as anti-sclerostin agents. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Effects of low dose doxycycline and caffeic acid phenethyl ester on sclerostin and bone morphogenic protein-2 expressions in experimental periodontitis |
|
| dc.type |
info:eu-repo/semantics/article |
|