| dc.creator |
B Akalin, Ramadan |
|
| dc.creator |
cevikbas, Halime |
|
| dc.creator |
Berisha, Avni |
|
| dc.creator |
ORAL, AYHAN |
|
| dc.creator |
TINAZ, GÜLGÜN |
|
| dc.creator |
ULUSOY, Seyhan |
|
| dc.date |
2022-07-01T00:00:00Z |
|
| dc.date.accessioned |
2023-01-09T12:00:36Z |
|
| dc.date.available |
2023-01-09T12:00:36Z |
|
| dc.identifier |
212a8add-c49c-4cd0-81a7-3c8921807338 |
|
| dc.identifier |
10.2217/fmb-2021-0174 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/212a8add-c49c-4cd0-81a7-3c8921807338/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/97643 |
|
| dc.description |
Aim: To investigate the hypothesis that zeolites interfere with quorum-sensing (QS) systems of Chromobacterium violaceum and Pseudomonas aeruginosa by adsorbing N-acyl homoserine lactone (AHL) signal molecules. Methods: QS inhibition by zeolite 4A was investigated using an AHL-based bioreporter assay. The adsorption of the AHLs was evaluated by performing inductively coupled plasma-optical emission spectroscopy and confirmed by Monte Carlo and molecular dynamic simulations. Results: Zeolite 4A reduced the violacein production in C. violaceum by over 90% and the biofilm formation, elastase and pyocyanin production in P. aeruginosa by 87, 68 and 98%, respectively. Conclusion: Zeolite 4A disrupts the QS systems of C. violaceum and P. aeruginosa by means of adsorbing 3-oxo-C6-AHL and 3-oxo-C12-AHL signaling molecules and can be developed as a novel QS jammer to combat P. aeruginosa-related infections. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Zeolite 4A as a jammer of bacterial communication in Chromobacterium violaceum and Pseudomonas aeruginosa |
|
| dc.type |
info:eu-repo/semantics/article |
|