| dc.creator |
Ocal, Ozgur |
|
| dc.creator |
NAZIROĞLU, Mustafa |
|
| dc.date |
2022-05-01T00:00:00Z |
|
| dc.date.accessioned |
2023-01-09T12:01:00Z |
|
| dc.date.available |
2023-01-09T12:01:00Z |
|
| dc.identifier |
2b093cd2-7675-4673-ae8b-cd04496d31c9 |
|
| dc.identifier |
10.1016/j.cbi.2022.109914 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/2b093cd2-7675-4673-ae8b-cd04496d31c9/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/97689 |
|
| dc.description |
Cisplatin (CiSP) induced-overload Ca2+ entry results in the increase of mitochondrial oxidative stress and apoptosis in the cancer cell. TRPM2 cation channel is gated by the cytosolic ADP-ribose (ADPR) and reactive oxygen species (ROS). The high content of polyunsaturated fatty acid (PUFA) in the brain is a main target of ROS. Eicosapentaenoic acid (EPA) induces oxidant action via the enhance of PUFA content in the glioblastoma (DBTRG) cells. We hypothesized that a combination of CiSP and EPA may offer a potential therapy in the DBTRG cell by exerting the antitumor, oxidant, and apoptotic actions and stimulating Ca2+ influx and TRPM2 activity. In the DBTRG cells, we induced four groups as control, EPA (30 mu M for 24 h), CiSP (25 mu M for 24 h), and CiSP + EPA. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Eicosapentaenoic acid enhanced apoptotic and oxidant effects of cisplatin via activation of TRPM2 channel in brain tumor cells |
|
| dc.type |
info:eu-repo/semantics/article |
|