| dc.creator |
TOĞAY, Vehbi Atahan |
|
| dc.creator |
KARABACAK, Pınar |
|
| dc.creator |
Celik, Dilek Asci |
|
| dc.date |
2022-07-01T00:00:00Z |
|
| dc.date.accessioned |
2023-01-09T12:03:25Z |
|
| dc.date.available |
2023-01-09T12:03:25Z |
|
| dc.identifier |
62978e22-d81c-4200-baa0-d1be1e3a1d0c |
|
| dc.identifier |
10.1016/j.mrgentox.2022.503516 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/62978e22-d81c-4200-baa0-d1be1e3a1d0c/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/97924 |
|
| dc.description |
Sepsis is an excessive host response to infection; septic shock is a more severe clinical condition. We studied 43 sepsis patients, 32 septic-shock patients, and a group of healthy controls. The patients' Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation (APACHE) 2 score were much higher in the septic-shock group than in the sepsis group. We used the comet assay to measure lymphocyte DNA damage; the damage scores were significantly higher in both the sepsis and the septic-shock groups compared to the healthy controls. There was no statistically significant difference between the sepsis and septic-shock groups. We also compared DNA damage levels of intubated vs. non-intubated patients. DNA damage was significantly higher in non-intubated patients compared to intubated patients, for both the sepsis and the septic-shock groups. Early intubation may be beneficial in non-intubated patients who have high levels of DNA damage. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Lymphocyte DNA damage in sepsis and septic-shock intensive-care patients: Damage is greater in non-intubated patients |
|
| dc.type |
info:eu-repo/semantics/article |
|