| dc.creator |
Özkahraman, Didem |
|
| dc.creator |
Selçuk, Esma |
|
| dc.creator |
Şahin Calapoğlu, Nilüfer |
|
| dc.creator |
Calapoğlu, Mustafa |
|
| dc.creator |
Şahin, Uğur |
|
| dc.date |
2022-08-01T00:00:00Z |
|
| dc.date.accessioned |
2023-01-09T12:07:10Z |
|
| dc.date.available |
2023-01-09T12:07:10Z |
|
| dc.identifier |
b70dae7f-8a01-48d3-a94e-8788034be17f |
|
| dc.identifier |
10.22312/sdusbed.1115667 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/b70dae7f-8a01-48d3-a94e-8788034be17f/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/98287 |
|
| dc.description |
<jats:p xml:lang="en">There is compelling evidence that the gastric peptide ghrelin and its growth hormone secretagogue G protein-coupled receptor play an important role in glucose metabolism and energy homeostasis. Therefore, these genes carrying susceptibility alleles for Type 2 diabetes are considered as potential candidates.A case-control cross-sectional association study was conducted in Isparta region, including 75 Type 2 diabetes patients and 100 Turkish adult individuals, including 25 controls. Four promoters (rs26311, rs26312, rs27647, rs3755777) and an intronic (rs35683) region in the ghrelin gene and an intronic (rs509035) and a 3'UTR (rs565105) region in the ghrelin receptor are associated with type 2 diabetes by selecting single nucleotide polymorphisms Matrix Assisted Laser Desorption /Ionization was investigated using the Time of Flight Mass Spectrometer system.A significant relationship was found between type 2 diabetes and two single-nucleotide polymorphisms: rs27647 in the promoter region of the ghrelin gene and rs35683 in intron 1 (P&lt;0.05).In conclusion, the findings suggest that ghrelin polymorphisms may predispose to disease development in the Type 2 diabetes population living in the Isparta region.</jats:p> |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/openAccess |
|
| dc.title |
Relationship of Ghrelin and Ghrelin Receptor Polymorphisms with Type 2 Diabetes |
|
| dc.type |
info:eu-repo/semantics/article |
|