| dc.creator |
Kortholt, Arjan |
|
| dc.creator |
Nederveen-Schippers, Laura M. |
|
| dc.creator |
Terheyden, Susanne |
|
| dc.date |
2016-12-01T00:00:00Z |
|
| dc.date.accessioned |
2023-01-09T12:09:36Z |
|
| dc.date.available |
2023-01-09T12:09:36Z |
|
| dc.identifier |
ecf29bf3-1536-407d-b7c7-5d8b126a54d0 |
|
| dc.identifier |
10.1042/bst20160224 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/ecf29bf3-1536-407d-b7c7-5d8b126a54d0/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/98518 |
|
| dc.description |
Mutations in the human leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of hereditary Parkinson's disease (PD). LRRK2 belongs to the Roco family of proteins, which are characterized by the presence of a Ras of complex proteins domain (Roc), a C-terminal of Roc domain (COR) and a kinase domain. Despite intensive research, much remains unknown about activity and the effect of PD-associated mutations. Recent biochemical and structural studies suggest that LRRK2 and Roco proteins are noncanonical G-proteins that do not depend on guanine nucleotide exchange factors or GTPase-activating proteins for activation. In this review, we will discuss the unusual G-protein cycle of LRRK2 in the context of the complex intramolecular LRRK2 activation mechanism. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/openAccess |
|
| dc.title |
The unconventional G-protein cycle of LRRK2 and Roco proteins |
|
| dc.type |
info:eu-repo/semantics/article |
|