| dc.creator |
Erarslan, Ayse Seda |
|
| dc.creator |
CESUR, GÖKHAN |
|
| dc.creator |
ÇEVİK, ÖZGE |
|
| dc.creator |
ÖZMERDİVENLİ, RECEP |
|
| dc.creator |
Gumus, Erkan |
|
| dc.creator |
ŞİRİNYILDIZ, FERHAT |
|
| dc.date |
2023-01-01T00:00:00Z |
|
| dc.date.accessioned |
2024-08-26T12:05:28Z |
|
| dc.date.available |
2024-08-26T12:05:28Z |
|
| dc.identifier |
0995946b-0b74-445a-959d-45e7226bb9fc |
|
| dc.identifier |
10.1080/15376516.2023.2187729 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/0995946b-0b74-445a-959d-45e7226bb9fc/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/98674 |
|
| dc.description |
Ulcerative Colitis (UC) is a disease that negatively affects quality of life and is associated with sustained oxidative stress, inflammation and intestinal permeability. Vitamin D and Curcumin; It has pharmacological properties beneficial to health, including antioxidant and anti-inflammatory properties. Our study investigates the role of Vitamin D and Curcumin in acetic acid-induced acute colitis model. To investigate the effect of Vitamin D and Curcumin, Wistar-albino rats were given 0.4 mcg/kg Vitamin D (Post-Vit D, Pre-Vit D) and 200 mg/kg Curcumin (Post-Cur, Pre-Cur) for 7 days and acetic acid was injected into all rats except the control group. Our results; colon tissue TNF-alpha, IL-1 beta, IL-6, IFN-gamma and MPO levels were found significantly higher and Occludin levels were found significantly lower in the colitis group compared to the control group (p < 0.05). TNF-alpha and IFN-gamma levels decreased and Occludin levels increased in colon tissue of Post-Vit D group compared to colitis group (p < 0.05). IL-1 beta, IL-6 and IFN-gamma levels were decreased in colon tissue of Post-Cur and Pre-Cur groups (p < 0.05). MPO levels in colon tissue decreased in all treatment groups (p < 0.05). Vitamin D and Curcumin treatment significantly reduced inflammation and restored the normal histoarchitecture of the colon. From the present study findings, we can conclude that Vitamin D and Curcumin protect the colon from acetic acid toxicity with their antioxidant and anti-inflammatory potential.Brief synopsis: In this study; distal colon, distal ileum, jejunum and serum physiopathology in colitis induced by acetic acid and intestinal permeability were investigated. The roles of vitamin D and curcumin in this process were evaluated. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Therapeutic and prophylactic role of vitamin D and curcumin in acetic acid-induced acute ulcerative colitis model |
|
| dc.type |
info:eu-repo/semantics/article |
|