| dc.creator |
Sofu, Ümran |
|
| dc.creator |
KUL, DİLEK |
|
| dc.creator |
ÖZTÜRK, GÖKÇE |
|
| dc.date |
2024-12-01T00:00:00Z |
|
| dc.date.accessioned |
2025-02-25T10:16:51Z |
|
| dc.date.available |
2025-02-25T10:16:51Z |
|
| dc.identifier |
0aa647be-4640-480e-8ead-bc510b1fde6b |
|
| dc.identifier |
10.1007/s00706-024-03264-7 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/0aa647be-4640-480e-8ead-bc510b1fde6b/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/98849 |
|
| dc.description |
Novel voltammetric methods were developed for the determination of donepezil, an acetylcholinesterase inhibitor, using the prepared carbon paste electrode. As a result of the optimization, the carbon paste composition was determined as 25% mineral oil and 75% graphite powder. Quantitative analysis of donepezil was carried out by differential pulse voltammetry (DPV) or square wave voltammetry (SWV) in Britton-Robinson buffer at pH 8.0. Linear ranges were obtained as 0.1‒20 µM with a detection limit of 26.3 nM for DPV and 0.08‒10 µM with a detection limit of 20.4 nM for SWV. The accuracy of the developed methods was obtained as 101.08% and 100.73% for DPV and SWV, respectively, with recovery from pharmaceutical dosage form, indicating that the determination of donepezil could be successfully accomplished without the interference of excipients. Graphical Abstract: (Figure presented.) |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Development of low-cost, fast, and sensitive voltammetric methods for the determination of donepezil using unmodified carbon paste electrode |
|
| dc.type |
info:eu-repo/semantics/article |
|