| dc.creator |
Aktepe, Evrim |
|
| dc.creator |
Kıyat, Esra |
|
| dc.creator |
Ertürk, Emre |
|
| dc.creator |
Bedir, Mehmet |
|
| dc.creator |
Kumbul, Duygu |
|
| dc.creator |
Işık, Ümit |
|
| dc.date |
2024-06-01T00:00:00Z |
|
| dc.date.accessioned |
2025-02-25T10:18:13Z |
|
| dc.date.available |
2025-02-25T10:18:13Z |
|
| dc.identifier |
1f1b2b86-0bc8-4025-8b1c-7cf117728c52 |
|
| dc.identifier |
10.1080/20473869.2023.2301185v |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/1f1b2b86-0bc8-4025-8b1c-7cf117728c52/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/99000 |
|
| dc.description |
<p>Introduction: The objective of our study is to clarify the involvement of the HMGB1/RAGE/TLR4/NF-kB axis,</p><p>a crucial component in inflammation, in the etiopathogenesis of autism spectrum disorder (ASD).</p><p>Method: We analyzed the levels of HMGB1, RAGE, TLR4, and NF-kB in serum from 80 children (40 with</p><p>ASD and 40 controls). All participants’ sociodemographic characteristics were recorded. In order to</p><p>determine the severity of the disorder, the Aberrant Behavior Checklist, Childhood Autism Rating Scale, and</p><p>Autism Behavior Checklist were administered to the ASD group.</p><p>Result: While the soluble TLR4 level was significantly higher in the ASD group (p<0.001), other parameters</p><p>examined did not show significant differences between groups. Furthermore, soluble TLR4 serum level was</p><p>positively correlated with Problem Behavior Checklist hyperactivity subscale scores (p¼0.031), and RAGE</p><p>serum level was negatively correlated with ABC Stereotype score (p¼0.001).</p><p>Discussion: It was thought that serum TLR4 levels may be important in the etiology of ASD. TLR4 levels are</p><p>linked to symptoms like hyperactivity in autism, which suggests that this parameter could be used as a</p><p>clinical guide. Further research is required to substantiate our discoveries and to clarify the involvement of</p><p>HMGB1, RAGE, TLR4, and NF-kB in the etiopathogenesis of ASD</p> |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/openAccess |
|
| dc.title |
Comparison of HMGB1, RAGE, TLR4, and NF-κB levels in children and adolescents diagnosed with autism spectrum disorder with healthy controls |
|
| dc.type |
info:eu-repo/semantics/article |
|