| dc.creator |
Beydemir, Şükrü |
|
| dc.creator |
Arslan, Gülnur |
|
| dc.creator |
Özçelik, Azime Berna |
|
| dc.creator |
Akdağ, Mevlüt |
|
| dc.creator |
Demir, Yeliz |
|
| dc.date |
2021-04-11T00:00:00Z |
|
| dc.date.accessioned |
2025-02-25T10:20:23Z |
|
| dc.date.available |
2025-02-25T10:20:23Z |
|
| dc.identifier |
3d1255fe-b100-456b-b840-db26bddb392f |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/3d1255fe-b100-456b-b840-db26bddb392f/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/99414 |
|
| dc.description |
<p>Aldose reductase is an enzyme that is responsible for the convertion of glucose to sorbitol. Increasedactivity of this pathway has been associated with diabetic complications thus making aldose reductaseenzyme a pharmacological target(1).There are some compounds which were evaulated in clinical trialsbearing pyridazinone moiety like ponalrestat. So, pyridazinone is a heterocyclic core having a potentialfor inhibiton of aldose reductase and chalcones are priviliged structures having antioxidantactivity(2,,3).Moreover, after tetramethyleneglutaric acid had been shown as an aldose reductaseinhibitor, various acid derivatives were synthesized and evaluated for aldose reductase inhibition(4).Given these data, combination of these structures can give rise to potent inhibitors of aldose reductaseand also antioxidant compounds. In this study, we synthesized a representing compound of 2-(6-Chalcoxy-Pyridazin-3(2H)-One-2-yl) Acetic Acid serie and performed molecular modelling studies of this compound. The success of synthesis was confirmed evaluating 1H-NMR and LC-MS spectra. Then, the biological activity of the compound was evaluated. <br></p> |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Synthesis and Molecular Modelling of 2-[6-(4-(3-(4-metoxyphenyl)-prop-2- enoil)phenoxy)pyridazin-3(2H)-one-2-yl)] Acetic Acid |
|
| dc.type |
info:eu-repo/semantics/conferenceObject |
|