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<p>Origanum species, which are widely used and marketed as spices, occupy a large place amongplants collected from nature. The genus Origanum, belonging to the Labiatae family, consists of manyspecies and subspecies with great interspecific and intraspecific diversity. More than half of the thymeexported from our country is obtained from cultivated thyme culture production. The thyme speciesOriganum onites and Origanum vulgare subsp. are grown around Isparta, Denizli and Izmir. Among thespecies traded in Turkey, Origanum onites L. is the most collected and exported species. The balls ofOriganum onites L., which form the leaf and flower collection, are consumed as spices. The essential oil ofOriganum onites L., which contains significant amounts of carvacrol and thymol, has antibacterial,antispasmodic, antiseptic, antimicrobial, cytotoxic, antioxidant and antifungal activity and the source of thetherapeutic effect is shown to be carvacrol. The essential oil of the plant is used in food as well as inmedicine and perfumery.In this study, essential oil was obtained from Origanum onites plant by distillation of water vapor. Theessential oil was analyzed by GC/MSD instrument. According to the results, the main component carvacrolwas determined as 73.11%. In this study, high purity carvacrol should be used. So, purification of thenaturally occurring carvacrol compound in thyme was carried out using flash chromatography method andobtained %97,48 purity carvacrol. It is necessary to enable carvacrol to behave like the active ingredient ofan antibiotic drug. Encapsulation method was considered as a method that can penetrate the cell wall andincrease its effectiveness. In order to increase the effectiveness of this compound, the LiposomeEncapsulation method was used, which can protect the molecule and facilitate its passage through the cellwall. </p> |
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