<p><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 508.816px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.06542) translateY(9.47266%);">Amaç</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 527.362px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 527.362px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.989427) translateY(9.47266%);">Multipl skleroz (MS), santral sinir sisteminin ön planda</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 545.908px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 545.908px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.01623) translateY(9.47266%);">beyaz cevherini etkileyen kronik inflamatuar demiye</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 545.908px; left: 446.314px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 564.454px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 564.454px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.01127) translateY(9.47266%);">linizan hastalığıdır. Kognitif bozukluk relapsing remit</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 564.454px; left: 446.305px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 583px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 583px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.0239) translateY(9.47266%);">ting multipl skleroz (RRMS) hastalarında sık karşıla</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 583px; left: 446.305px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 601.546px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 601.546px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.02585) translateY(9.47266%);">şılan bir sorundur ve yaşam kalitesi üzerinde önemli</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 620.092px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.02361) translateY(9.47266%);">rol oynamaktadır. MS hastalarının %30-70’inde kog</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 620.092px; left: 446.299px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 638.638px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 638.638px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.02087) translateY(9.47266%);">nitif bozukluk görülür. Bozukluklar tipik olarak bellek,</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 657.184px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.00628) translateY(9.47266%);">dikkat, bilgi işleme fonksiyonlarındadır. Bu çalışmada</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 675.73px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.00398) translateY(9.47266%);">erken evre MS hastalarındaki bilişsel bozulmanın pa</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 675.73px; left: 446.305px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 694.276px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 694.276px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.00029) translateY(9.47266%);">terninin belirlenmesi amaçlanmıştır.</span><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 731.368px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 731.368px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.05268) translateY(9.47266%);">Gereç ve Yöntem</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 749.914px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 749.914px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.04866) translateY(9.47266%);">Çalışmaya 30 RRMS hastası ve 30 sağlıklı gönüllü</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 768.46px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.997643) translateY(9.47266%);">dahil edilmiştir. Tüm deneklere sözel ve görsel bellek,</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 787.006px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.996917) translateY(9.47266%);">dikkat, yürütücü işlevler, görsel-uzamsal işlevler, lisan</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 805.552px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.02864) translateY(9.47266%);">ve genel akıcı zekayı kapsayan geniş bir nöropsiko</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 805.552px; left: 446.314px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 824.098px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 824.098px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.02631) translateY(9.47266%);">lojik test bataryası uygulanmıştır. Özürlülük ve işlev</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 824.098px; left: 446.297px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 842.644px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 842.644px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.02358) translateY(9.47266%);">selliğin etkilenen kognitif alanlarla ilişkisi değerlendi</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 842.644px; left: 446.314px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 861.19px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 861.19px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.00013) translateY(9.47266%);">rilmiştir.</span><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 898.282px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 898.282px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.10581) translateY(9.47266%);">Bulgular</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 916.828px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 916.828px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.02614) translateY(9.47266%);">Çalışmaya alınan MS hastaları ve sağlıklı gönüllüle</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 916.828px; left: 446.314px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 935.374px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 935.374px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.041) translateY(9.47266%);">rin ortalama yaş ve eğitim süreleri arasında anlamlı</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 953.92px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.03343) translateY(9.47266%);">bir farklılık yoktu. MS’li hastalarda ortalama hastalık</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 972.466px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.0138) translateY(9.47266%);">süresi 62.20 ± 52.70 ay ve ortalama tanı alma süresi</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 991.012px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.99268) translateY(9.47266%);">39.16 ± 39.17 ay idi. Ortalama atak sayısı 3.13 ± 1.90</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 1009.56px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.03671) translateY(9.47266%);">idi. Ortalama EDSS puanı 1.38 ± 1.31 idi. Psikomo</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 1009.56px; left: 446.304px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 1028.1px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 1028.1px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.01352) translateY(9.47266%);">tor hız ve dikkat işlevlerini değerlendiren bir test olan</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 470.317px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.03168) translateY(9.47266%);">İz Sürme Testi A ve B alt-testlerinde MS’li hastaların</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 488.863px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.04331) translateY(9.47266%);">başarımı kontrol grubundakinden belirgin derecede</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 507.409px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.00016) translateY(9.47266%);">daha düşüktü (p=0.005).</span><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 544.501px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 544.501px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.07801) translateY(9.47266%);">Sonuç</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 563.047px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 563.047px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.982941) translateY(9.47266%);">MS hastaları dikkat ve yürütücü işlevleri değerlendiren</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 581.593px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.02094) translateY(9.47266%);">tüm testlerde daha kötü bir başarım sergilemiştir. Bu</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 600.139px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.0066) translateY(9.47266%);">kötü başarım Multipl Skleroz İşlevsel Bileşiği (MSFC)</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 618.685px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.03104) translateY(9.47266%);">ve Genişletilmiş Özürlülük Durum Ölçeği (EDSS) ile</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 637.231px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.04866) translateY(9.47266%);">bağıntılıdır. MS hastalarında temel olarak bellek ve</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 655.777px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.01372) translateY(9.47266%);">dikkat bozuklukları bildirilmiştir. Bulgularımız çalışma</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 674.323px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.00873) translateY(9.47266%);">belleği, dikkat ve yürütücü işlev bozukluğunun hasta</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 674.323px; left: 827.668px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 692.869px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 692.869px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.01587) translateY(9.47266%);">lığın erken evrelerinden itibaren diğer bulgulara eşlik</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 711.415px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.00027) translateY(9.47266%);">edebileceğini düşündürmektedir.</span><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 748.507px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 748.507px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.08117) translateY(9.47266%);">Anahtar Kelimeler:</span><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 748.507px; left: 606.397px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.210341) translateY(9.47266%);"> </span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 748.507px; left: 615.436px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.07203) translateY(9.47266%);">Bellek, Dikkat, EDSS, Görsel</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 767.053px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.01477) translateY(9.47266%);">uzamsal işlevler, MSFC, Multipl skleroz, Yürütücü iş</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 767.053px; left: 827.676px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 785.599px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1) translateY(9.47266%);">AmaçMultipl skleroz (MS), santral sinir sisteminin ön plandabeyaz cevherini etkileyen kronik inflamatuar demiyelinizan hastalığıdır. Kognitif bozukluk relapsing remitting multipl skleroz (RRMS) hastalarında sık karşılaşılan bir sorundur ve yaşam kalitesi üzerinde önemlirol oynamaktadır. MS hastalarının %30-70’inde kognitif bozukluk görülür. Bozukluklar tipik olarak bellek,dikkat, bilgi işleme fonksiyonlarındadır. Bu çalışmadaerken evre MS hastalarındaki bilişsel bozulmanın paterninin belirlenmesi amaçlanmıştır.Gereç ve YöntemÇalışmaya 30 RRMS hastası ve 30 sağlıklı gönüllüdahil edilmiştir. Tüm deneklere sözel ve görsel bellek,dikkat, yürütücü işlevler, görsel-uzamsal işlevler, lisanve genel akıcı zekayı kapsayan geniş bir nöropsikolojik test bataryası uygulanmıştır. Özürlülük ve işlevselliğin etkilenen kognitif alanlarla ilişkisi değerlendirilmiştir.BulgularÇalışmaya alınan MS hastaları ve sağlıklı gönüllülerin ortalama yaş ve eğitim süreleri arasında anlamlıbir farklılık yoktu. MS’li hastalarda ortalama hastalıksüresi 62.20 ± 52.70 ay ve ortalama tanı alma süresi39.16 ± 39.17 ay idi. Ortalama atak sayısı 3.13 ± 1.90idi. Ortalama EDSS puanı 1.38 ± 1.31 idi. Psikomotor hız ve dikkat işlevlerini değerlendiren bir test olanİz Sürme Testi A ve B alt-testlerinde MS’li hastalarınbaşarımı kontrol grubundakinden belirgin derecededaha düşüktü (p=0.005).SonuçMS hastaları dikkat ve yürütücü işlevleri değerlendirentüm testlerde daha kötü bir başarım sergilemiştir. Bukötü başarım Multipl Skleroz İşlevsel Bileşiği (MSFC)ve Genişletilmiş Özürlülük Durum Ölçeği (EDSS) ilebağıntılıdır. MS hastalarında temel olarak bellek vedikkat bozuklukları bildirilmiştir. Bulgularımız çalışmabelleği, dikkat ve yürütücü işlev bozukluğunun hastalığın erken evrelerinden itibaren diğer bulgulara eşlikedebileceğini düşündürmektedir.<br></span><br></p><p><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 508.816px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.06542) translateY(9.47266%);">Amaç</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 527.362px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 527.362px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.989427) translateY(9.47266%);">Multipl skleroz (MS), santral sinir sisteminin ön planda</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 545.908px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 545.908px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.01623) translateY(9.47266%);">beyaz cevherini etkileyen kronik inflamatuar demiye</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 545.908px; left: 446.314px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 564.454px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 564.454px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.01127) translateY(9.47266%);">linizan hastalığıdır. Kognitif bozukluk relapsing remit</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 564.454px; left: 446.305px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 583px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 583px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.0239) translateY(9.47266%);">ting multipl skleroz (RRMS) hastalarında sık karşıla</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 583px; left: 446.305px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 601.546px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 601.546px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.02585) translateY(9.47266%);">şılan bir sorundur ve yaşam kalitesi üzerinde önemli</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 620.092px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.02361) translateY(9.47266%);">rol oynamaktadır. MS hastalarının %30-70’inde kog</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 620.092px; left: 446.299px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 638.638px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 638.638px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.02087) translateY(9.47266%);">nitif bozukluk görülür. Bozukluklar tipik olarak bellek,</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 657.184px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.00628) translateY(9.47266%);">dikkat, bilgi işleme fonksiyonlarındadır. Bu çalışmada</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 675.73px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.00398) translateY(9.47266%);">erken evre MS hastalarındaki bilişsel bozulmanın pa</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 675.73px; left: 446.305px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 694.276px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 694.276px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.00029) translateY(9.47266%);">terninin belirlenmesi amaçlanmıştır.</span><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 731.368px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 731.368px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.05268) translateY(9.47266%);">Gereç ve Yöntem</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 749.914px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 749.914px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.04866) translateY(9.47266%);">Çalışmaya 30 RRMS hastası ve 30 sağlıklı gönüllü</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 768.46px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.997643) translateY(9.47266%);">dahil edilmiştir. Tüm deneklere sözel ve görsel bellek,</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 787.006px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.996917) translateY(9.47266%);">dikkat, yürütücü işlevler, görsel-uzamsal işlevler, lisan</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 805.552px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.02864) translateY(9.47266%);">ve genel akıcı zekayı kapsayan geniş bir nöropsiko</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 805.552px; left: 446.314px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 824.098px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 824.098px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.02631) translateY(9.47266%);">lojik test bataryası uygulanmıştır. Özürlülük ve işlev</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 824.098px; left: 446.297px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 842.644px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 842.644px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.02358) translateY(9.47266%);">selliğin etkilenen kognitif alanlarla ilişkisi değerlendi</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 842.644px; left: 446.314px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 861.19px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 861.19px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.00013) translateY(9.47266%);">rilmiştir.</span><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 898.282px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 898.282px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.10581) translateY(9.47266%);">Bulgular</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 916.828px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 916.828px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.02614) translateY(9.47266%);">Çalışmaya alınan MS hastaları ve sağlıklı gönüllüle</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 916.828px; left: 446.314px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 935.374px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 935.374px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.041) translateY(9.47266%);">rin ortalama yaş ve eğitim süreleri arasında anlamlı</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 953.92px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.03343) translateY(9.47266%);">bir farklılık yoktu. MS’li hastalarda ortalama hastalık</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 972.466px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.0138) translateY(9.47266%);">süresi 62.20 ± 52.70 ay ve ortalama tanı alma süresi</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 991.012px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.99268) translateY(9.47266%);">39.16 ± 39.17 ay idi. Ortalama atak sayısı 3.13 ± 1.90</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 1009.56px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.03671) translateY(9.47266%);">idi. Ortalama EDSS puanı 1.38 ± 1.31 idi. Psikomo</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 1009.56px; left: 446.304px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 1028.1px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 1028.1px; left: 87.619px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.01352) translateY(9.47266%);">tor hız ve dikkat işlevlerini değerlendiren bir test olan</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 470.317px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.03168) translateY(9.47266%);">İz Sürme Testi A ve B alt-testlerinde MS’li hastaların</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 488.863px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.04331) translateY(9.47266%);">başarımı kontrol grubundakinden belirgin derecede</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 507.409px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.00016) translateY(9.47266%);">daha düşüktü (p=0.005).</span><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 544.501px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 544.501px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.07801) translateY(9.47266%);">Sonuç</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 563.047px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 563.047px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.982941) translateY(9.47266%);">MS hastaları dikkat ve yürütücü işlevleri değerlendiren</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 581.593px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.02094) translateY(9.47266%);">tüm testlerde daha kötü bir başarım sergilemiştir. Bu</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 600.139px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.0066) translateY(9.47266%);">kötü başarım Multipl Skleroz İşlevsel Bileşiği (MSFC)</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 618.685px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.03104) translateY(9.47266%);">ve Genişletilmiş Özürlülük Durum Ölçeği (EDSS) ile</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 637.231px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.04866) translateY(9.47266%);">bağıntılıdır. MS hastalarında temel olarak bellek ve</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 655.777px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.01372) translateY(9.47266%);">dikkat bozuklukları bildirilmiştir. Bulgularımız çalışma</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 674.323px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.00873) translateY(9.47266%);">belleği, dikkat ve yürütücü işlev bozukluğunun hasta</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 674.323px; left: 827.668px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 692.869px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 692.869px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.01587) translateY(9.47266%);">lığın erken evrelerinden itibaren diğer bulgulara eşlik</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 711.415px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.00027) translateY(9.47266%);">edebileceğini düşündürmektedir.</span><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 748.507px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all;"></span><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 748.507px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.08117) translateY(9.47266%);">Anahtar Kelimeler:</span><span style="height: 1em; font-family: g_d0_f6, sans-serif; font-size: 15.455px; position: absolute; top: 748.507px; left: 606.397px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.210341) translateY(9.47266%);"> </span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 748.507px; left: 615.436px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.07203) translateY(9.47266%);">Bellek, Dikkat, EDSS, Görsel</span><span style="height: 1em; font-family: g_d0_f8, sans-serif; font-size: 15.455px; position: absolute; top: 767.053px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1.01477) translateY(9.47266%);">uzamsal işlevler, MSFC, Multipl skleroz, Yürütücü iş</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 767.053px; left: 827.676px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(0.998113) translateY(9.47266%);">-</span><span style="height: 1em; font-family: g_d0_f7, sans-serif; font-size: 15.455px; position: absolute; top: 785.599px; left: 468.987px; transform-origin: left bottom; white-space: pre; pointer-events: all; transform: scaleX(1) translateY(9.47266%);">AmaçMultipl skleroz (MS), santral sinir sisteminin ön plandabeyaz cevherini etkileyen kronik inflamatuar demiyelinizan hastalığıdır. Kognitif bozukluk relapsing remitting multipl skleroz (RRMS) hastalarında sık karşılaşılan bir sorundur ve yaşam kalitesi üzerinde önemlirol oynamaktadır. MS hastalarının %30-70’inde kognitif bozukluk görülür. Bozukluklar tipik olarak bellek,dikkat, bilgi işleme fonksiyonlarındadır. Bu çalışmadaerken evre MS hastalarındaki bilişsel bozulmanın paterninin belirlenmesi amaçlanmıştır.Gereç ve YöntemÇalışmaya 30 RRMS hastası ve 30 sağlıklı gönüllüdahil edilmiştir. Tüm deneklere sözel ve görsel bellek,dikkat, yürütücü işlevler, görsel-uzamsal işlevler, lisanve genel akıcı zekayı kapsayan geniş bir nöropsikolojik test bataryası uygulanmıştır. Özürlülük ve işlevselliğin etkilenen kognitif alanlarla ilişkisi değerlendirilmiştir.BulgularÇalışmaya alınan MS hastaları ve sağlıklı gönüllülerin ortalama yaş ve eğitim süreleri arasında anlamlıbir farklılık yoktu. MS’li hastalarda ortalama hastalıksüresi 62.20 ± 52.70 ay ve ortalama tanı alma süresi39.16 ± 39.17 ay idi. Ortalama atak sayısı 3.13 ± 1.90idi. Ortalama EDSS puanı 1.38 ± 1.31 idi. Psikomotor hız ve dikkat işlevlerini değerlendiren bir test olanİz Sürme Testi A ve B alt-testlerinde MS’li hastalarınbaşarımı kontrol grubundakinden belirgin derecededaha düşüktü (p=0.005).SonuçMS hastaları dikkat ve yürütücü işlevleri değerlendirentüm testlerde daha kötü bir başarım sergilemiştir. Bukötü başarım Multipl Skleroz İşlevsel Bileşiği (MSFC)ve Genişletilmiş Özürlülük Durum Ölçeği (EDSS) ilebağıntılıdır. MS hastalarında temel olarak bellek vedikkat bozuklukları bildirilmiştir. Bulgularımız çalışmabelleği, dikkat ve yürütücü işlev bozukluğunun hastalığın erken evrelerinden itibaren diğer bulgulara eşlikedebileceğini düşündürmektedir.<br></span>ObjectiveMultiple sclerosis (MS) is a chronic-imflammatorydemyelinating central nervus system disease affectingmainly the white matter. Cognitive impairment isa common problem in relapsing-remitting multiplesclerosis (RRMS) patients and plays a major rolein the quality of life. Cognitive impairment occurs in30-70% of patients with MS. Deficits typically occurin memory, attention and information processingfunctions. In this study it is aimed to determine pattern&nbsp;of cognitive impairment in MS patients who are in theearly hase of disease.Material and MethodThirty RRMS patients and 30 healthy volunteers wereincluded in the study. All subjects were administered acomprehensive neuropsychological test battery whichencompases verbal and visual memory, attention,executive functions, visual spatial functions, languageand general fluid intelligence. The relation of disabilityand functionality with affected cognitive domains werealso evaluated.ResultsThere was no significant difference mean age andduration of education between the MS patients andhealthy controls. Mean duration of disease in MSpatients is 62.20 ± 52.70 mounth and mean time todiagnosis is 39.16 ± 39.17 mounth, Mean number ofattack is 3.13 ± 1.90 and mean EDSS score is 1.38 ±1.31. In Trail Making Test A and B, which is a test thatevaluates psychomotor speed and attention functions,patients with MS had significantly lower performancethan control group.ConclusionMS patient exhibited a worse performance in alltests evaluating attention and executive functions.This worse performance was correlated withMultiple Sclerosis Functional Composite (MSFC)and Expanded Diasability Status Scale (EDSS).MS patients are reported to have mainly memoryand attention deficits. Our results suggest that aworking memory and attention deficits and executivedysfunction may associate with other fin<br></p>