In the study, it is aimed to analyze the impact of the COVID-19 epidemic on the health system performance of OECD countries by using multi-criteria decision-making methods. The research population consists of 38 OECD countries. In the study, using TOPSIS, COPRAS, VIKOR and GIA methods, the countries with the best performance and the safest in the COVID-19 epidemic are ranked and compared. According to the TOPSIS and VIKOR analysis applied, Germany; according to the GIA, Japan; and according to the COPRAS analysis, New Zealand are the countries with the best performance in the health system during the COVID-19 period. At the same time, in the evaluation of COVID-19 safe countries, it is concluded that Germany according to the results of TOPSIS and GIA analysis; and South Korea according to the result of VIKOR analysis are the safest countries with the best performance. The COVID-19 outbreak is thought to be a stimulus for countries to evaluate their health systems and to take the safest countries with the best performance as a guide. As a matter of fact, considering the health plans implemented by these countries, it is recommended to improve health resources in terms of quality and quantity against possible epidemic threats.