Osteogenesis imperfecta (OI) is an autosomal dominant disease that affects the teeth and the musculoskeletal system. Orthodontic treatment in OI patients may be risky due to the fragility of dental hard tissues. Clear aligners may be considered a suitable orthodontic treatment method for these patients. A 30-year-old female OI patient with Angle Class I malocclusion, open bite, and crowding underwent prosthetic treatment after 15 months of clear aligner orthodontic treatment. Aesthetic rehabilitation was achieved with clear aligner treatment and prosthetic restorations. It is possible to obtain more aesthetic results with orthodontic treatments before prosthetic restorations in the oral rehabilitation of patients with skeletal and dental malocclusions. In orthodontic treatments in adult patients with systemic diseases, the use of clear aligners both minimizes the risk and provides a more comfortable process.