Objectve: The aim of this study is to determine the effect of neuromuscular fatigue created in the core region on the biomechanics of landing. Materals and Methods: Healthy individuals aged between 18-25 years and without any musculoskeletal injury that prevented them from performing the landing test were included in the study. In the study, cross-over randomization was applied. After the descriptive characteristics of the individuals (lower extremity length, Q angle, range of motion etc.) participating in the study were recorded, core region endurance was evaluated with curl-up test, static back endurance test (Biering Sorenson test) and horizontal side bridge test. Subjective fatigue protocol was created with the prone bridge test. The effect of the fatigue caused by the prone bridge test performed during applied time on the biomechanics landing was examined with the 'Landing Error Scoring System'. Results: The study included 21 women (77.8%) and six men (22.2%) whose age was 21.7±0.2 (21-25) years, height 168.7±1.6 (156-190) cm, body weight 59.3±1.6 (46-80) kg and body mass index 20.8±0.5 (17.5-28.8) kg/m2. It was determined that fatigue caused by the prone bridge test perfor med during applied time did not make a difference in the landing error score of the participants (p=0.545). It was determined that the results of the curl-up test and right horizontal side bridge test, in which endurance of the core region was determined, revealed a negative linear relationship with the landing error scores obtained after the fatigue protocol. Concluson: Increasing core region endurance of healthy individuals is associated with the response of lower extremity biomechanics to fatigue. The refore, it is recommended that endurance exercises for the core region should be made a part of training programs.