Objective: Chorioamnionitis (CRY), with membrane rupture, preterm labor, prolonged labor, smoking, and bacterial or viral infection origin; is a condition that presents a risk for both maternal and neonatal sequelae. Our study aimed to investigate the effect of Salubrinal (SLB), an endoplasmic reticulum (ER) stress inhibitor, against damage to placental tissue and fetal brain in the Lipopolysaccharide (LPS) induced CRY model. Material and Method: In this study, 24 Wistar Albino rats on the 17th gestational day; were divided into 4 groups; control, LPS (1 mg/kg intraperitoneal (ip)), LPS + SLB (1 mg/kg LPS ip and 1 mg/kg SLB ip) and SLB (1 mg/kg ip). After an experimental hysterectomy, the placenta and fetal brain tissues were taken into formaldehyde solution for histopathological analysis. Results: According to the findings obtained; widespread congestion in the basal zone, degeneration of trophoblastic cells in the labyrinth zone, and inflammatory cell infiltrations in both basal and labyrinth zones were observed in the placental tissues of the LPS group. No pathology was detected in only the SLB group. While edema and congestion were detected in the ventricular and intermediate zones in the fetal brain tissues of the LPS group, a significant improvement was observed in these findings with SLB treatment. Conclusion: As a result; ER stress is one of the mechanisms that play a role in placental tissue and fetal brain damage due to CRY, and SLB therapy might prevent this damage.