<p><span style="color: rgb(17, 17, 17); font-family: Poppins; font-size: 14px;">Background: Today, the frequency of seeking an aesthetic smile in patients who apply to dentistry clinics has increased compared to the past. This expectation is fundamental in restorations in the anterior region, as well as shape, size, and proportion, as well as color harmony. One of the most challenging stages in prosthetic dental treatment is to find the natural and correct color for the planned restorations. This study aims to examine the most commonly used visual color matching and color matching using Vita 3D Master color guide in terms of CIE94 and CIEDE2000 formulations in comparison and to examine the repeatability and reliability of the methods.</span><br style="color: rgb(17, 17, 17); font-family: Poppins; font-size: 14px;"><br style="color: rgb(17, 17, 17); font-family: Poppins; font-size: 14px;"><span style="color: rgb(17, 17, 17); font-family: Poppins; font-size: 14px;">Methods: 70 3rd-grade students who did not have color education clinically or theoretically as a curriculum were included in the study. The 3D-Master Tooth Guide with 26 tabs was used for color matching. Six target colors (1M2, 2M2, 2R2.5, 3M3, 3L1.5, 4R1.5) were determined, and an intraoral spectrophotometer was used for color measurements of the target tabs and all color guide tabs. CIE L*a*b* color coordinates were recorded to evaluate color differences for CIE94 and CIEDE2000. To test the reproducibility of this method, the same color-matching protocol was repeated for all participants after one month.</span><br style="color: rgb(17, 17, 17); font-family: Poppins; font-size: 14px;"><br style="color: rgb(17, 17, 17); font-family: Poppins; font-size: 14px;"><span style="color: rgb(17, 17, 17); font-family: Poppins; font-size: 14px;">Results: In the study, no significant difference was found in any of the colors in both methods (CIE94 and CIEDE2000) in the measurements repeated one month later (p&gt;0.05). There was a significant difference in the mean measurement results between CIE94 and CIEDE2000 formulations (p&lt;0.05).</span><br style="color: rgb(17, 17, 17); font-family: Poppins; font-size: 14px;"><br style="color: rgb(17, 17, 17); font-family: Poppins; font-size: 14px;"><span style="color: rgb(17, 17, 17); font-family: Poppins; font-size: 14px;">Conclusion: There is a significant difference between CIE94 and CIEDE2000 formulations (p&lt;0.05). All the methods examined were found to be reproducible and reliable.</span><br></p>