Vitamin B12 is a water-soluble vitamin essential for growth and development in humans. It is required for methylation reactions and DNA synthesis. Vitamin B12 deficiency has a causal relationship with a variety of disease and is also recognized as a risk factor for some others. Megaloblastic anemia and neurological disorders are the most prevalent disorders seen with vitamin B12 deficiency. In this review, vitamin B12's absorption, the main physiological functions and the role of it in pathogenesis of neurological disorders is summarized.Key words: Vitamin B12, cobalamin, neuropathy, myelin
ÖzetB12 vitamini insanlarda büyüme ve gelişme için hayati önemi olan suda çözünür bir vitamindir. Metilasyon reaksiyonları ve DNA sentezi için gereklidir. Vitamin B12 eksikliği bazı hastalıklarla nedensel olarak ilişkilidir, başka bazı hastalıklarda da bir risk faktörü olduğu bilinmektedir. Megaloblastik anemi ve nörolojik hastalıklar en yaygın olanlarıdır. Bu derleme vitamin B12'nin absorbsiyonu, temel fizyolojik işlevleri ve nörolojik hastalıkların patogenezindeki rolünü özetlenmiştir.Anahtar kelimeler: Vitamin B12, kobalamin, nöropati, miyelinAbstractVitamin B12 is a water-soluble vitamin essential for growth and development in humans. It is required for methylation reactions and DNA synthesis. Vitamin B12 deficiency has a causal relationship with a variety of disease and is also recognized as a risk factor for some others. Megaloblastic anemia and neurological disorders are the most prevalent disorders seen with vitamin B12 deficiency. In this review, vitamin B12's absorption, the main physiological functions and the role of it in pathogenesis of neurological disorders is summarized.Key words: Vitamin B12, cobalamin, neuropathy, myelin