ABSTRACTObjective: The purpose of this study was to evaluate the levels of salivary malondyaldehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GP-x) levels in patients with periodontal disease and hyperlipidemia.Method: One hundred and twenty three subjects with hyperlipidemia aged 30 to 57 and 68 systemically healthy controls (C) aged 31 to 54 were included in the study. Hyperlipidemic groups were divided into two groups as suggested diet (HD) and prescribed statin (HS). All of the groups were divided into three subgroups as healthy (h), gingivitis (g) and periodontitis (p). The clinical periodontal parameters, including plaque index (PI), gingival index (GI), probing pocket (PPD) depth, percentage of bleeding on probing (BOP-%), and clinical attachment level (CAL) were recorded. Serum lipids and salivary MDA, SOD, GSH and GP-x levels were evaluated.Results: MDA is significantly and positively correlated with GI, BOP-% and the ratio of total cholesterol/high density lipoprotein in both hyperlipidemic groups. In the HSh group, salivary SOD level was higher than in the HSp group.Discussion: The salivary MDA and SOD levels are parameters which may play role in the association between periodontal disease and hyperlipidemia. Further longitudinal studies in larger populations with different periodontitis and hyperlipidemia phases are needed to clarify this association.Key words: Gingivitis; periodontitis; hyperlipidemia; malondyaldehyde; superoxide dismutase; glutathione; glutathione peroxidase.ÖzetAmaç: Bu çalışmada amaç periodontal hastalıklı ve hiperlipidemili bireylerde salya malondialdehit (MDA), süperoksit dismutaz (SOD), glutatyon (GSH) ve glutatyon peroksidaz (GP-x) seviyelerinin değerlendirilmesidir.Yöntem: Çalışma popülasyonunu yaşları 30 ila 57 arasında değişen 123 hiperlipidemili ve yaşları 31 ila 54 arasında değişen 68 sistemik olarak sağlıklı (K) birey olmak üzere toplam 191 birey oluşturdu. Hiperlipidemik gruplar diyet önerilen (HD) ve statin önerilen (HS) gruplar olmak üzere iki gruba ayrıldı. Bütün çalışma grupları periodontal sağlıklı (s), gingivitisli (g) ve periodontitili (p) olmak üzere üç gruba ayrıldı. Tüm bireylerin plak indeksi (Pİ), gingival indeks (Gİ), cep derinliği (CD), klinik ataçman seviyesi (KAS) ve sondlamada kanama varlığı yüzdesi (SK-%)' ni içeren ölçümlerden oluşan klinik periodontal parametreleri kaydedildi. Serum lipidleri ve salya MDA, SOD, GSH ve GP-x seviyeleri değerlendirildi.Sonuçlar: Salya MDA ile Gİ, SK-% ve total kolesterol/yüksek densiteli lipoprotein oranı arasındaki pozitif korelasyonlar hiperlipidemili gruplarda anlamlı idi. HSs grubunda salya SOD seviyesi, HSp grubuna göre istatistiksel olarak anlamlı artış gösterdi.Tartışma: Salya MDA ve SOD seviyeleri, oksidatif stres ile ilişkili olarak periodontal hastalık ve hiperlipidemi ilişkisinde rol oynayabilen parametreler olabilir. Bu konuda, periodontitis ve hiperlipideminin farklı safhalarına sahip daha geniş popülasyonlarda, uzun dönem ileri çalışmalara ihtiyaç vardır.Anahtar kelimeler: Gingivitis; periodontitis; hiperlipidemi; malondialdehit; süperoksit dismutaz; glutatyon; glutatyon peroksidaz.AbstractObjective: The purpose of this study was to evaluate the levels of salivary malondyaldehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GP-x) levels in patients with periodontal disease and hyperlipidemia.Method: One hundred and twenty three subjects with hyperlipidemia aged 30 to 57 and 68 systemically healthy controls (C) aged 31 to 54 were included in the study. Hyperlipidemic groups were divided into two groups as suggested diet (HD) and prescribed statin (HS). All of the groups were divided into three subgroups as healthy (h), gingivitis (g) and periodontitis (p). The clinical periodontal parameters, including plaque index (PI), gingival index (GI), probing pocket (PPD) depth, percentage of bleeding on probing (BOP-%), and clinical attachment level (CAL) were recorded. Serum lipids and salivary MDA, SOD, GSH and GP-x levels were evaluated.Results: MDA is significantly and positively correlated with GI, BOP-% and the ratio of total cholesterol/high density lipoprotein in both hyperlipidemic groups. In the HSh group, salivary SOD level was higher than in the HSp group.Discussion: The salivary MDA and SOD levels are parameters which may play role in the association between periodontal disease and hyperlipidemia. Further longitudinal studies in larger populations with different periodontitis and hyperlipidemia phases are needed to clarify this association.Key words: Gingivitis; periodontitis; hyperlipidemia; malondyaldehyde; superoxide dismutase; glutathione; glutathione peroxidase.