Platelet-rich fibrin (PRF) is a naturally derived fibrinscaffold and second-generation platelet concentrate with great potential forpromoting wound healing and the regenerative process via the secretion ofdifferent cytokines and growth factors, enhanced osteoblast adhesion, andaugmentation of collagen protein expression. Given the significance of thescope of PRF in the field of orthopedic surgery, this study presents an overviewfor the role of PRF in the recovery and the regenerative process with emphasison its rationale for use and outcome in orthopedic surgery. In conclusion, PRFoffers a new dimension for clinical research with expanded range of potentialapplications in orthopedic surgery with a simpler preparation protocol, astronger and more stable fibrin polymerization leading to a physiologicarchitecture, occurrence of natural clot formation allowing formation of aflexible and fine fibrin network and a continual and steady release ofcytokines and growth factors, mimicking the requirements of the reparativetissue and wound healing processes.