There are many application fields for fast neutrons. The main application fields of the fast neutrons are accelerator-driven sub-critical systems (ADS) and fusion-fission (hybrid) reactor systems for fission energy production. Thorium (Th) and uranium (U) are nuclear fuels in fusion-fission (hybrid) reactor systems and bismuth (Bi) is also the target nucleus in the ADS reactor systems. In this study, neutron production cross sections produced by (d, xn) reactions for spallation targets such as Bi-209, Th-232, U-235 and U-238 have been investigated. New evaluated hybrid model and geometry dependent hybrid model have been used to calculate the pre-equilibrium neutron production cross sections. For the reaction equilibrium component, Weisskopf-Ewing model calculations have been preferred. The obtained results have been discussed and compared with the available experimental data and found in agreement with each other. (C) 2010 Elsevier Ltd. All rights reserved.