In this study, by using equilibrium and pre-equilibrium reaction mechanisms, the (p,xn) cross-sections of the spallation neutron target nuclei Cr-50,Cr-52,Cr-53,Cr-54 and Cu-63,Cu-65 were investigated for incident proton energies up to 100 MeV. The excitation functions for pre-equilibrium reaction mechanisms were calculated by using a hybrid model, a geometry dependent hybrid model, the full exciton model and the cascade exciton model. Equilibrium effects were calculated according to the Weisskopf-Ewing model. The calculation results were also compared with the measurements in literature. (c) 2008 Elsevier Ltd. All rights reserved.