<p>Background: Psoriasis is a chronic systemic inflammatory disease frequently associated with</p><p>serious comorbidities.</p><p>Objectives: To investigate the systemic inflammatory burden in psoriasis and to assess the</p><p>correlation between traditional and novel inflammatory markers and the severity of the disease.</p><p>Methods: This cross-sectional study was conducted on 60 patients with psoriasis vulgaris and</p><p>50 healthy volunteers. Data including demographics, Psoriasis Area and Severity Index scores,</p><p>and laboratory results were analyzed and compared.</p><p>Results: Compared with the control group, the psoriatic patients had significantly higher high</p><p>sensitive C-reactive protein, serum amyloid A, erythrocyte sedimentation rate, leukocyte,</p><p>neutrophil, neutrophil-to-lymphocyte ratio, monocyte to high density lipoprotein (HDL) cholesterol</p><p>ratio, and aspartate aminotransferase levels, and significantly lower HDL cholesterol</p><p>levels (p &lt; 0.05). No significant difference was found in procalcitonin, lymphocyte, monocyte,</p><p>hemoglobin, red blood cell distribution width, platelet, mean platelet volume, platelet distribution</p><p>width, lymphocyte-to-monocyte ratio, anti-cyclic citrullinated peptide, glucose, alanine</p><p>aminotransaminase, blood urea nitrogen, creatinine, triglyceride, total cholesterol, and LDL</p><p>cholesterol levels between the two groups (p &gt; 0.05). The Psoriasis Area and Severity Index</p><p>score was positively correlated with high-sensitivity C-reactive protein, serum amyloid A, and</p><p>monocyte to HDL cholesterol ratio, and negatively correlated with lymphocyte-to-monocyte</p><p>ratio (p &lt; 0.05).</p><p>Study limitations: This was a single-center study with relatively limited numbers of patients</p><p>and controls.</p>