In this present study, by using equilibrium and pre-equilibrium reaction mechanisms, the (p, n) cross-section values for some target (A = 25-240) nuclei were investigated in a range of 10-40 MeV incident energy. The excitation functions for pre-equilibrium calculations were newly calculated by using hybrid model, geometry dependent hybrid model, full-exciton model, and cascade exciton model. The reaction equilibrium component was calculated with a traditional compound nucleus model developed by Weisskopf-Ewing. Calculation results were compared with the available excitation functions measurements in literature.