Background and objectives: Host modulation therapies (anti-inflammatory drugs, bone-stimulating agents, antiproteinase etc.) target the inhibition or stabilization of tissue breakdown. The aim of the present study was to evaluate the effects of caffeic acid phenethyl ester (CAPE) and/or low dose doxycycline (LDD) administrations on alveolar bone loss (ABL), serum cytokines and gingival apoptosis, as well as the levels of oxidants and antioxidants in rats with ligature-induced periodontitis.