Different irrigation methods (S: Sprinkler; D: Drip), nitrogen forms (L: Liquid; G: Granule), water and nitrogen levels (based on applied line source sprinkler) and watermelon varieties (P: Paladin; M: Madera) were studied in the experiment. The research was conducted in Research and Production Farm of Cukurova University. Experimental design was strip for the first year and split-strip for the second year. Irrigation water was calculated using cumulative evaporation (Ep) from Class A-pan. Significant linear relationships were obtained between the yield and irrigation water, and between the yield and evapotranspiration at 1% confidence level. Yield response factor (Ky) values were determined as 1.07 for total yield and 1.49 for marketable yield. Since Ky> 1, watermelon was sensitive to water deficiency. In addition, total water use efficiencies (TWUE) and irrigation water use efficiencies (IWUE) ranged from 1.80 to 11.33 kg da(-1) mm(-1) and from 7.29 to 16.47 kg da(-1) mm(-1) respectively. This finding indicated that WUE and IWUE values increased with the decreasing evapotranspiration and irrigation water.