<p class="MsoNormal" style="margin-bottom:4.0pt;line-height:12.0pt;mso-line-height-rule:exactly"><span lang="EN-US" style="font-size:10.0pt">In this study, thesimultaneous determination of Lisinopril (LIS)<span style="color:#222222"> andHydrochlorothiazide(HCT)</span> in drug samples by chemometric approaches usingUV spectrophotometry has been reported as a simple alternative to usingseparate models for each component. Spectra of LIS <span style="color:#222222">andHCT </span>were recorded at several concentrations within their ranges and wereused to compute the calibration mixture between wavelengths 200 and 350 nm atan interval of 5 nm was used for data acquisition. Principal componentregression was used for chemometric analysis of data and the parameters of thechemometric procedures were optimized. The analytical performances of thischemometric method was characterized by predicted residual error sum of squares(PRESS), standard error of prediction (SEP) and recoveries (%) and werecompared with each other. A series of synthetic solution containing differentconcentrations of LIS and HCT were used to check the prediction ability of theprincipal component regression. This method was successfully applied to realsamples, with no interference from excipients as indicated by recovery studyresults. The outcomes acquired in this examination firmly urge us to applythese strategies for a standard investigation and quality control of the twomedications.<o:p></o:p></span></p>