Exoskeleton robots are used as assistive limbs for elderly persons, rehabilitation for paralyzed persons or power augmentation purposes for healthy persons. The similarity of the exoskeleton robots and human body neuro-muscular system maximizes the device performance. Human body neuro-muscular system provides a flexible and safe movement capability with minimum energy consumption by varying the stiffness of the human joints regularly. Similar to human body, variable stiffness actuators should be used to provide a flexible and safe movement capability in exoskeletons. In the present day, different types of variable stiffness actuator designs are used, and the studies on these actuators are still continuing rapidly. As exoskeleton robots are mobile devices working with the equipment such as batteries, the motors used in the design are expected to have minimal power requirements. In this study, antagonistic, pre-tension and controllable transmission ratio type variable stiffness actuators are compared in terms of energy efficiency and power requirement at an optimal (medium) walking speed for ankle joint. In the case of variable stiffness, the results show that the controllable transmission ratio type actuator compared with the antagonistic design is more efficient in terms of energy consumption and power requirement.