The leaves of TSL (Thymbra Spicata Labiatae), which include plant sterols and stanols, are used in the treatment of hypercholesterolemia, which is a highly prevalent health problem. This study aimed to determine the histopathological effects of TSL oil and atorvastatin (ATS), also known as Karabas thyme, an herb in the Isparta region, on the biochemical parameters and the kidney tissues of the rats who received TSL oil and ATS in varying doses.