Objective: Platelet activation plays an important role in the development of cerebral arterial occlusion. Mean platelet volume (MPV) and platelet count are reported to be good indicators of platelet activity. The aim of this study was to investigate the relationship between MPV, platelet count, and the platelet-lymphocyte ratio with endovascular recanalisation success in acute middle cerebral artery (MCA) M1 occlusions.