Description:
<div class="abstract-content selected" id="enc-abstract" style="box-sizing: inherit; clear: left; color: rgb(33, 33, 33); font-family: BlinkMacSystemFont, -apple-system, "Segoe UI", Roboto, Oxygen, Ubuntu, Cantarell, "Fira Sans", "Droid Sans", "Helvetica Neue", sans-serif; font-size: 16px;"><p style="box-sizing: inherit; line-height: 1.5; margin-top: 1.2rem; margin-bottom: 1.2rem;"><b style="box-sizing: inherit;">Background</b>: Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio are electrocardiographic markers and indices of ventricular arrhythmogenic events. We aimed to investigate ventricular repolarization in normal weight, overweight, obese and morbidly obese individuals by using ECG parameters including the above markers.<b style="box-sizing: inherit;">Methods:</b> A total of 310 obese patients with various cardiac complaints, who were admitted to our outpatient clinic between May 2020 and January 2021, were prospectively included in the study. Using the World Health Organization (WHO) body mass index (BMI) classification, patients were divided into four groups: normal weight (18.5-24.9 kg/m<span style="box-sizing: inherit; font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;">2</span>, n = 48), overweight (25-29.9 kg/m<span style="box-sizing: inherit; font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;">2</span>, n = 98), obese (30-39.9 kg/m<span style="box-sizing: inherit; font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;">2</span>, n = 119), and morbidly obese (>40 kg/m<span style="box-sizing: inherit; font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;">2</span>, n = 45).<b style="box-sizing: inherit;">Results:</b> The morbidly obese and normal groups were younger in age than the other two groups. The Tp-e interval values for Groups I-IV were 72.1 ± 6.9, 73.1 ± 6.2, 75.7 ± 7.3 and 81.1 ± 6.9, respectively, and significantly different (<i style="box-sizing: inherit;">P</i> < .001). We found that age, BMI, systolic blood pressure (BP) and diastolic BP were independent predictors of a prolonged Tp-e interval.<b style="box-sizing: inherit;">Conclusions:</b> The principal finding of our study was the gradual increase in Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio starting from the overweight stage and these parameters gradually increase in obese and morbidly obese patients. Additionally, systolic and diastolic blood pressure predicted Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio.</p></div><p style="box-sizing: inherit; line-height: 1.5; margin-top: 1.2rem; margin-bottom: 1.2rem; color: rgb(33, 33, 33); font-family: BlinkMacSystemFont, -apple-system, "Segoe UI", Roboto, Oxygen, Ubuntu, Cantarell, "Fira Sans", "Droid Sans", "Helvetica Neue", sans-serif; font-size: 16px;"><strong class="sub-title" style="box-sizing: inherit;">Keywords: </strong>Electrocardiogram; Tp-e interval; Tp-e/QTc ratio; blood pressure; obesity; ventricular repolarization.</p>