In humans, the coronary arteries course not only subepicardially but also intramyocardially. The intramyocardial course of the coronary artery is reported to lead to acute ischemic heart disease and, as well, it may be symptomless. The aim of this study was to investigate the long-term ischemic effects of bridged arteries on the myocardium, and was carried out on 8 autopsy hearts with myocardial bridges and 2 hearts without myocardial bridges. The samples from the myocardium were examined with light microscopy. In the myocardium supplied by the bridged arteries, it was observed that there was an increase in the intercellular connective tissue, which was rich in collagen bundles, lymphocytes, fibroblasts and macrophages. Compression of the coronary artery by myocardial bridges may cause chronic degenerative changes, which may remain silent for a long time.