In this study, sediment transport rate of the Kizilirmak River basin located in the tectonically active North Anatolian Fault Zone (NAFZ) is evaluated in order to determine the effects of the NAFZ on the Kizilirmak basin sediment transport rate. Vegetation covers the basin area is extracted from the LANDSAT ETM data by using Normalized Difference Vegetation Index (NDVI). On the other hand, topographic attributes (elevation, slope, curvature, and water catchment) were obtained from Digital Elevation Model (DEM) to detect areas associated with sediment transport and accumulation. GIS was used to extract topographic profiles along with the Kizilirmak River and attributes as well as for the implementation of the stream power index (SPI), topographic wetness index (TWI), sediment transport index (STI) and channel width. The relation with the derived indices and NAFZ is determined by integrating hot and cold spot clusters of indices values mapped with Getis-Ord Gi* statistics. According to the derived results which highlighted hot and cold spots of the index values helped to identify the relation between sediment transport rate of the basin area and NAFZ.