The present pilot study aimed to develop, implement, and evaluate an escape room game for oncologic emergencies. This quasi-experimental pilot study was developed and evaluated by teachers for an oncology nursing course. A total of 76 nursing students ​participated in the study. After completing the game, students were given access to the data collection tools including “Introductory Information Form, Instructional Materials Motivation Survey, Student Satisfaction and Self-Confidence in Learning Scale, Simulation Design Scale by clicking on a link at the end of the game. Findings revealed that the students participating in the escape room game were highly motivated, satisfied, and self-confident with learning, and they were also satisfied with the design of the game. There were statistical differences between the total and sub-dimension scores of the variables examined and the scales used (p < 0,05). The current study on the use of an oncological emergencies-themed escape room as a teaching and learning strategy has provided promising insights. In nursing education, traditionally dominated by theoretical and practical intensive content, current study findings underline the value of this innovative strategy in helping students to improve motivation, satisfaction, and confidence in learning.