In this research, the calculations have been done for α-emitters of 211At, which is a promising isotope in cyclotrons for radiotherapy. The scope of the study is to investigate the production parameters of 211At, which can be produced in the cyclotron by bombarding bismuth with an alpha particle beam for the 209Bi(α,2n)211At reaction. The total activity, reaction yield, and production cross–sections of 209Bi(α,2n)211At reaction have been calculated by using diverse level density models of the TALYS 1.95 code. Furthermore, recommended data with 95% confidence limits have been obtained. Experimental data available in the literature based on EXFOR compilation are used to compare the findings. Consequently, the required beam energy has been found to be 28 MeV to produce 211At.