The study aims to reveal the mediating role of trust in social media news in the effect of COVID- 19 vaccine literacy on individuals' attitudes towards vaccination. Individuals living in the central districts of Konya province constitute the scope of the study. This study was conducted between February 01-28, 2022, and in the research model created in the context of the purpose of the study, COVID-19 Vaccine Literacy (X) is the independent variable, Attitudes Towards COVID-19 Vaccine is the dependent variable, and Confirmation / Trust in Social Media News is the mediating variable. The findings for the variables showed that the participants' vaccine literacy (Mean=3.28), social media confirmation/trust (Mean=3.05) and attitudes towards vaccination (Mean=3.43) had a value above the average. As the results of correlation analysis findings, a weak positive significant relationship between social media/confirmation trust and COVID-19 Vaccine Literacy (r=.248; p=.000<.001) was found. However, significant relationship between other variables was not found. The independent variables of the research, COVID-19 Vaccine Literacy and Social Media Confirmation/Trust, do not have a significant contribution in explaining the dependent variable Attitudes Towards COVID-19 Vaccine. Nevertheless, it was observed that COVID-19 vaccine literacy explained 0.6% variance of the change in individuals' confirmation and trust in social media news (R^2=.061). The mediating effect of Confirmation/Trust in Social Media news on attitudes towards Covid-19 vaccine was not found. This research is important in terms of being a study that contributes to the literature by examining the mediating role of social media news confirmation/trust in the effect of Covid-19 vaccine literacy, a type of literacy, on attitudes towards vaccination.