<p>Schiff bases are compounds formed by the nucleophilic addition reaction of primary amineswith the activated carbonyl group of aldehydes or ketones and contain carbon-nitrogendouble bonds (-C=N-) [1]. Some studies have shown that the presence of an electron pair inan sp2 hybridized orbital of the nitrogen atom of Schiff bases is of great chemical andbiological importance. In addition, these compounds are excellent metal chelators,especially when bound to functional groups such as - OH or - SH [2]. Schiff bases are notonly easy to synthesize, but also find wide application in medicinal chemistry and thepharmaceutical industry, which has increased importance of these compounds [3]. Inaddition, Schiff bases showed antimicrobial [4], antiviral [4], antinociceptive [5], antiplatelet[5], antiproliferative [4,5], anticancer [4,5], and anticonvulsant [4,5] activities.Benzothiazolone is bicylic ring system of pharmaceutical importance due to its strong andimportant biological effects. In this study, new schiff base of Benzothiazolone-2(3H)-3-ilacetohyrazid derivates with substitue/nonsubstitueindol or substituepyridine aldehydeshave been microwave synthesized. Structures of the synthesized compounds were verifiedby 1H-NMR and LC-MS spectrospy methods<br></p>