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The Effect of Radiotherapy Technique on Carotid Artery Dose in Patients with Early Stage Glottic Larynx Cancer

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dc.creator ŞİRİN ÖZDEMİR, Beyza; AKDENİZ ÜNİVERSİTESİ
dc.creator CAN, Zeynep Rukiye Özge; AKDENİZ ÜNİVERSİTESİ
dc.date 2021-03-11T00:00:00Z
dc.date.accessioned 2021-12-03T11:46:53Z
dc.date.available 2021-12-03T11:46:53Z
dc.identifier https://dergipark.org.tr/tr/pub/sdutfd/issue/60659/623353
dc.identifier 10.17343/sdutfd.623353
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/94112
dc.description Objective: Theaim of this study was to compare two radiotherapy techniques in early stageglottic laryngeal cancer patients in terms of radiotherapy dose applied to thecarotid artery.Material - Methods:In this study, we included 10 early-stage (T1/2) glottic larynx cancerpatients. Both intensity-modulatedradiotherapy (IMRT) and 3-dimension conformal radiotherapy (3DCRT) treatmentplans were prepared for each patient. Treatment volumes (CTV, PTV) were createdfor all patients. The entire larynx was described as CTV to include both falseand true vocal cords, anterior-posterior commissures, arytenoids, aryepiglotticfolds, subglottic region. For planning target volüme (PTV), while 5-mm was addedto CTV in all directions, 3-mm margin was given to protect the carotid arteryand spinal cord in posterolaterally. Spinal cord and carotid artery werecontoured as the organ at risk (OAR). The doses of the target volumes, the OARvolumes, the homogeneity index (HI) were compared. Results: PTVparameters (Dmin, Dmean, Dmax, D90, D95) was compared in the 2 differenttechnique.  IMRT in comparison to 3DCRTsignificantly reduced the high-dose volumes (V30, V35, V50) of carotid artery(p < 0.001), but not to the low dose volume (V10). CI was similar (0.9 vs.0.9, p = 0.3) compared to 3DCRT. However, HI was significantly improved withIMRT (0.1 vs. 0.08, p < 0.001). The maximum dose of the spinal cord was lower in3DCRT compared to IMRT (18 Gy vs. 44Gy).Conclusion: IMRTis a superior radiotherapy (RT) technique in patients with T1/T2 glottic cancerin terms of protecting carotid artery.
dc.description Amaç: Buçalışmanın amacı, erken evre glottik larenks kanser tanılı hastalarda ikiradyoterapi tekniğinin karotis arter dozları açısından karşılaştırılmasıdır.Gereç - Yöntemler:Bu çalışmaya, 10 erken evre (T1 / 2) glottik larenks kanser tanılı hastayıdahil ettik. Her bir hasta için hem yoğunluk ayarlı radyoterapi (YART) hem de 3boyutlu konformal radyoterapi (3BKRT) tedavi planları hazırlandı. Tüm hastalariçin tedavi volümleri (CTV, PTV) oluşturuldu. Tüm larinks, gerçek ve yalancı vokalkordlar, anterior-posterior komissürler, aritenoidler, aryepiglottik kıvrımlar,subglottik bölge dahil edilecek şekilde klinik hedef volüm (CTV) olşturuldu.Planlanan hedef volümü (PTV) oluşturmak için, tüm yönlerde CTV'ye 5 mm eklenirken,karotis arter ve spinal kordu korumak adına posterolateral yönde 3 mm'lik marjverildi. T1/T2 glottik kanserlerde lenfatik nodal metastaz riski çok düşükolduğu için, elektif nodal ışınlama yapılmadı. Spinal kord ve karotis arterlerkritik organlar (OAR) olarak konturlandı. Hedef hacim dozları, OAR hacimleri,homojenlik indeksi (HI) karşılaştırıldı. Ek olarak, karotis arter için V30<% 20, V10 <% 50 değerlendirildi ve spinal kordun maksimum dozu 45Gy ilesınırlandırıldı. Conformite indeksi (CI) hesaplandı. İstatistiksel analiz içinMann Whitney testi kullanıldı ve p <0.05 anlamlı kabul edildi.Bulgular: PTVparametreleri (Dmin, Dmean, Dmax, D90, D95) iki farklı tekniktekarşılaştırıldı. 3BKRT’ye kıyasla YART, karotis arterde yüksek doz hacimlerini(V30, V35, V50) belirgin olarak düşürürken (p < 0.001), düşük doz hacimleri(V10) her iki teknikte de yüksek seyretti. Her iki teknikte de CI benzer olup(0.9 vs. 0.9, p = 0.3), HI YART’de daha iyiydi (0.1 vs. 0.08, p < 0.001).Spinal kord maksimum dozları 3BKRT’de daha düşüktü (18 Gy vs. 44Gy).Sonuç: IMRT,T1 / T2 glottik kanserli hastalarda karotis arterin korunması açısından üstünbir radyoterapi (RT) tekniğidir.
dc.format application/pdf
dc.language en
dc.publisher Süleyman Demirel Üniversitesi
dc.publisher Süleyman Demirel University
dc.source Volume: 28, Issue: 1 9-12 en-US
dc.source 1300-7416
dc.source 2602-2109
dc.source SDÜ Tıp Fakültesi Dergisi
dc.subject Radiotherapy,glottic cancer,carotid artery,3DCRT,IMRT
dc.subject Radyoterapi,Glottik kanser,Karotid arter,3BKRT,IMRT
dc.title The Effect of Radiotherapy Technique on Carotid Artery Dose in Patients with Early Stage Glottic Larynx Cancer en-US
dc.title Erken Evre Glottik Larenks Kanserli Hastalarda Radyoterapi Tekniğinin Karotis Arter Dozu Üzerine Etkisi tr-TR
dc.type info:eu-repo/semantics/article
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