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Global, regional, and national sex differences in the global burden of tuberculosis by HIV status, 1990–2019: results from the Global Burden of Disease Study 2019

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dc.creator Lal, Dharmesh Kumar
dc.creator Lak, Hassan Mehmood
dc.creator Kwarteng, Alexander
dc.creator Kumar, Nithin
dc.creator Kumar, Narinder
dc.creator Kumar, G Anil
dc.creator Kumar, Avinash
dc.creator Kucuk Bicer, Burcu
dc.creator Krishan, Kewal
dc.creator Koyanagi, Ai
dc.creator Koulmane Laxminarayana, Sindhura Lakshmi
dc.creator Koul, Parvaiz A
dc.creator Kosen, Soewarta
dc.creator Kisa, Sezer
dc.creator Kisa, Adnan
dc.creator Kim, Yun Jin
dc.creator Kim, Min Seo
dc.creator Khubchandani, Jagdish
dc.creator Khoja, Abdullah T
dc.creator Khatab, Khaled
dc.creator Khalilov, Rovshan
dc.creator Khajuria, Himanshu
dc.creator Kerbo, Amene Abebe
dc.creator Kendrick, Parkes J
dc.creator Kayode, Gbenga A
dc.creator Katoto, Patrick DMC
dc.creator Kandel, Himal
dc.creator Kanchan, Tanuj
dc.creator Kamath, Ashwin
dc.creator Kabir, Zubair
dc.creator Joukar, Farahnaz
dc.creator Joseph, Nitin
dc.creator Jonas, Jost B
dc.creator Jha, Ravi Prakash
dc.creator Jayaram, Shubha
dc.creator Jayapal, Sathish Kumar
dc.creator Javanmardi, Fatemeh
dc.creator Jain, Vardhmaan
dc.creator Jacobsen, Kathryn H
dc.creator Jaafari, Jalil
dc.creator Itumalla, Ramaiah
dc.creator Ismail, Nahlah Elkudssiah
dc.creator Irvani, Seyed Sina Naghibi
dc.creator Ilic, Milena D
dc.creator Ilic, Irena M
dc.creator Ibitoye, Segun Emmanuel
dc.creator Hussain, Rabia
dc.creator Househ, Mowafa
dc.creator Hostiuc, Mihaela
dc.creator Hosseinzadeh, Mehdi
dc.creator Holla, Ramesh
dc.creator Hezam, Kamal
dc.creator Hayat, Khezar
dc.creator Hassankhani, Hadi
dc.creator Hassan, Shoaib
dc.creator Hashi, Abdiwahab
dc.creator Hasaballah, Ahmed I
dc.creator Hargono, Arief
dc.creator Harapan, Harapan
dc.creator Haque, Shafiul
dc.creator Hanif, Asif
dc.creator Hamidi, Samer
dc.creator Haider, Mohammad Rifat
dc.creator Gupta, Vivek Kumar
dc.creator Gupta, Veer Bala
dc.creator Gupta, Sapna
dc.creator Gupta, Bhawna
dc.creator Goodridge, Amador
dc.creator Golechha, Mahaveer
dc.creator Ghashghaee, Ahmad
dc.creator Ghadiri, Keyghobad
dc.creator Geberemariyam, Biniyam Sahiledengle
dc.creator Garg, Tushar
dc.creator Garcia-Calavaro, Christian
dc.creator Garcia-Basteiro, Alberto L
dc.creator Frank, Tahvi D
dc.creator Foroutan, Masoud
dc.creator Fischer, Florian
dc.creator Filip, Irina
dc.creator Ferro Desideri, Lorenzo
dc.creator Fernandes, Eduarda
dc.creator Farzadfar, Farshad
dc.creator Faraon, Emerito Jose A
dc.creator Enany, Shymaa
dc.creator Emami, Amir
dc.creator Elhadi, Muhammed
dc.creator Eftekharzadeh, Sahar
dc.creator Doan, Linh Phuong
dc.creator Diaz, Daniel
dc.creator Dianatinasab, Mostafa
dc.creator Dhamnetiya, Deepak
dc.creator Darwesh, Aso Mohammad
dc.creator Daneshpajouhnejad, Parnaz
dc.creator Dandona, Rakhi
dc.creator Dandona, Lalit
dc.creator Dai, Xiaochen
dc.creator Dagnew, Amare Belachew
dc.creator Dadras, Omid
dc.creator Chattu, Vijay Kumar
dc.creator Chattu, Soosanna Kumary
dc.creator Chatterjee, Souranshu
dc.creator Charan, Jaykaran
dc.creator Carvalho, Felix
dc.creator Carter, Austin
dc.creator Butt, Zahid A
dc.creator Burugina Nagaraja, Sharath
dc.creator Buonsenso, Danilo
dc.creator Briko, Nikolay Ivanovich
dc.creator Boloor, Archith
dc.creator Bikbov, Boris
dc.creator Bijani, Ali
dc.creator Bhattacharyya, Krittika
dc.creator Bhattacharjee, Natalia V
dc.creator Bhardwaj, Pankaj
dc.creator Bhardwaj, Nikha
dc.creator Bhagavathula, Akshaya Srikanth
dc.creator Belgaumi, Uzma Iqbal
dc.creator Basu, Sanjay
dc.creator Barrow, Amadou
dc.creator Barra, Fabio
dc.creator Barqawi, Hiba Jawdat
dc.creator Banach, Maciej
dc.creator Baig, Atif Amin
dc.creator Babar, Zaheer-Ud-Din
dc.creator B, Darshan B
dc.creator Azhar, Gulrez Shah
dc.creator Atre, Sachin R
dc.creator Asemahagn, Mulusew A
dc.creator Arja, Asrat
dc.creator Rahmani, Amir Masoud
dc.creator Arabloo, Jalal
dc.creator Anwer, Razique
dc.creator Antony, Catherine M
dc.creator Antonio, Carl Abelardo T
dc.creator Androudi, Sofia
dc.creator Anderson, Jason A
dc.creator Amit, Arianna Maever L
dc.creator Amini, Saeed
dc.creator Alvis-Guzman, Nelson
dc.creator Al-Raddadi, Rajaa M
dc.creator Alizade, Hesam
dc.creator Alipour, Vahid
dc.creator Ali, Liaqat
dc.creator Ali, Beriwan Abdulqadir
dc.creator Alene, Kefyalew Addis
dc.creator Ranasinghe, Priyanga
dc.creator Rao, Chythra R
dc.creator Alemayehu, Yosef
dc.creator Alahdab, Fares
dc.creator Al Hamad, Hanadi
dc.creator Rawaf, David Laith
dc.creator Rawaf, Salman
dc.creator Akunna, Chisom Joyqueenet
dc.creator Aklilu, Addis
dc.creator Ahmed Salih, Yusra
dc.creator Ahmed Rashid, Tarik
dc.creator Reitsma, Marissa B
dc.creator Ahmadi, Sepideh
dc.creator Ahmad, Sajjad Ahmad
dc.creator Ahinkorah, Bright Opoku
dc.creator Afzal, Saira
dc.creator Adnani, Qorinah Estiningtyas Sakilah
dc.creator Adebayo, Oladimeji M
dc.creator Remuzzi, Giuseppe
dc.creator Renzaho, Andre M N
dc.creator Abu-Gharbieh, Eman
dc.creator Abosetugn, Akine Eshete
dc.creator Reta, Melese Abate
dc.creator Abolhassani, Hassan
dc.creator Feldman, Rachel
dc.creator Bryazka, Dana
dc.creator Jahagirdar, Deepa
dc.creator Ross, Jennifer M
dc.creator Rezaei, Nima
dc.creator Tarkang, Elvis Enowbeyang
dc.creator Rezahosseini, Omid
dc.creator Rezai, Mohammad sadegh
dc.creator Rezapour, Aziz
dc.creator Roshandel, Gholamreza
dc.creator LeGrand, Kate E
dc.creator Biehl, Molly H
dc.creator Novotney, Amanda
dc.creator Roshchin, Denis O
dc.creator Maddison, Emilie R
dc.creator Sabour, Siamak
dc.creator Saif-Ur-Rahman, K.M.
dc.creator Salam, Nasir
dc.creator Samadi Kafil, Hossein
dc.creator Samaei, Mehrnoosh
dc.creator Samy, Abdallah M
dc.creator Vongpradith, Avina
dc.creator Ma, Jianing
dc.creator Ledesma, Jorge R
dc.creator Tekalegn, Yohannes
dc.creator Rafiei, Alireza
dc.creator Radfar, Amir
dc.creator Pribadi, Dimas Ria Angga
dc.creator Prashant, Akila
dc.creator Pourshams, Akram
dc.creator Postma, Maarten J
dc.creator Polibin, Roman V
dc.creator Pirestani, Majid
dc.creator Perico, Norberto
dc.creator Pepito, Veincent Christian Filipino
dc.creator Rahim, Fakher
dc.creator Rahimi-Movaghar, Vafa
dc.creator Pawar, Shrikant
dc.creator Paul, Pintu
dc.creator Paudel, Rajan
dc.creator Pattanshetty, Sanjay M
dc.creator Pashazadeh Kan, Fatemeh
dc.creator Parthasarathi, Ramakrishnan
dc.creator P A, Mahesh
dc.creator Oren, Eyal
dc.creator Olagunju, Andrew T
dc.creator Odukoya, Oluwakemi Ololade
dc.creator Oancea, Bogdan
dc.creator Nuñez-Samudio, Virginia
dc.creator Ntsekhe, Mpiko
dc.creator Nnaji, Chukwudi A
dc.creator Nixon, Molly R
dc.creator Nguyen, Trang Huyen
dc.creator Neupane Kandel, Sandhya
dc.creator Nazari, Javad
dc.creator Nayak, Biswa Prakash
dc.creator Narasimha Swamy, Sreenivas
dc.creator Naqvi, Atta Abbas
dc.creator Nair, Suma
dc.creator Nair, Sanjeev
dc.creator Nagarajan, Ahamarshan Jayaraman
dc.creator Moore, Catrin E
dc.creator Montasir, Ahmed Al
dc.creator Moni, Mohammad Ali
dc.creator Molokhia, Mariam
dc.creator Mohammed, Shafiu
dc.creator Mohammadian-Hafshejani, Abdollah
dc.creator Mohammadi, Mokhtar
dc.creator Moghadaszadeh, Masoud
dc.creator Mithra, Prasanna
dc.creator Misra, Sanjeev
dc.creator Rahman, Mahfuzar
dc.creator Mheidly, Nour Mheidly
dc.creator Mestrovic, Tomislav
dc.creator Mesregah, Mohamed Kamal
dc.creator Mersha, Amanual Getnet
dc.creator Merie, Hayimro Edemealem
dc.creator Menezes, Ritesh G
dc.creator Mendoza, Walter
dc.creator Memish, Ziad A
dc.creator Mehta, Saurabh
dc.creator Martins-Melo, Francisco Rogerlândio
dc.creator Malik, Ahmad Azam
dc.creator Majeed, Azeem
dc.creator Mahajan, Preetam Bhalchandra
dc.creator Madi, Deepak
dc.creator Madhava Kunjathur, Shilpashree
dc.creator Machado, Daiane Borges
dc.creator Lozano, Rafael
dc.creator Lopukhov, Platon D
dc.creator Liu, Xuefeng
dc.creator Lin, Christine
dc.creator Lee, Wei-Chen
dc.creator Lee, Shaun Wen Huey
dc.creator Lasrado, Savita
dc.creator Rahman, Mosiur
dc.creator Landires, Iván
dc.creator Saroshe, Satish
dc.creator Sartorius, Benn
dc.creator Sathian, Brijesh
dc.creator Sawyer, Susan M
dc.creator Senthilkumaran, Subramanian
dc.creator Seylani, Allen
dc.creator Shafaat, Omid
dc.creator Shaikh, Masood Ali
dc.creator Sharafi, Kiomars
dc.creator Shetty, Ranjitha S
dc.creator Shigematsu, Mika
dc.creator Shin, Jae Il
dc.creator Silva, João Pedro
dc.creator Singh, Jitendra Kumar
dc.creator Sinha, Smriti
dc.creator Christopher, Devasahayam J
dc.creator Chu, Dinh-Toi
dc.creator Claassens, Mareli M
dc.creator Steiropoulos, Paschalis
dc.creator Sufiyan, Mu'awiyyah Babale
dc.creator Skryabin, Valentin Yurievich
dc.creator Skryabina, Anna Aleksandrovna
dc.creator Spurlock, Emma Elizabeth
dc.creator Sreeramareddy, Chandrashekhar T
dc.creator Yunusa, Ismaeel
dc.creator Zastrozhin, Mikhail Sergeevich
dc.creator Zastrozhina, Anasthasia
dc.creator Zhang, Zhi-Jiang
dc.creator Zumla, Alimuddin
dc.creator Tabuchi, Takahiro
dc.creator Tadesse, Eyayou Girma
dc.creator Mokdad, Ali H
dc.creator Tamir, Zemenu
dc.creator Kyu, Hmwe Hmwe
dc.creator Murray, Christopher J L
dc.creator Hay, Simon I
dc.creator Yiğit, Vahit
dc.creator Vos, Theo
dc.creator Naghavi, Mohsen
dc.creator Lim, Stephen S
dc.creator Reiner Jr, Robert C
dc.creator Salomon, Joshua A
dc.creator Yu, Chuanhua
dc.creator Yonemoto, Naohiro
dc.creator Yi, Siyan
dc.creator Yeshaw, Yigizie
dc.creator Yazie, Taklo Simeneh Yazie
dc.creator Yahyazadeh Jabbari, Seyed Hossein
dc.creator Wubishet, Befikadu Legesse
dc.creator Woldekidan, Mesfin Agachew
dc.creator Whisnant, Joanna L
dc.creator Walters, Magdalene K
dc.creator Waheed, Yasir
dc.creator Vu, Giang Thu
dc.creator Vo, Bay
dc.creator Valadan Tahbaz, Sahel
dc.creator Umeokonkwo, Chukwuma David
dc.creator Ullah, Anayat
dc.creator Tsegaye, Gebiyaw Wudie
dc.creator Tsegaye, Berhan
dc.creator Tran, Bach Xuan
dc.creator Tobe-Gai, Ruoyan
dc.creator Tleyjeh, Imad I
dc.creator Thapar, Rekha
dc.creator Tessema, Belay
dc.creator Tesfay, Fisaha Haile
dc.date 2021-01-01T00:00:00Z
dc.date.accessioned 2022-05-10T11:15:31Z
dc.date.available 2022-05-10T11:15:31Z
dc.identifier 16890606-7706-41ed-adb1-840a0ea3ea19
dc.identifier 10.1016/s1473-3099(21)00449-7
dc.identifier https://avesis.sdu.edu.tr/publication/details/16890606-7706-41ed-adb1-840a0ea3ea19/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/96486
dc.description © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Tuberculosis is a major contributor to the global burden of disease, causing more than a million deaths annually. Given an emphasis on equity in access to diagnosis and treatment of tuberculosis in global health targets, evaluations of differences in tuberculosis burden by sex are crucial. We aimed to assess the levels and trends of the global burden of tuberculosis, with an emphasis on investigating differences in sex by HIV status for 204 countries and territories from 1990 to 2019. Methods: We used a Bayesian hierarchical Cause of Death Ensemble model (CODEm) platform to analyse 21 505 site-years of vital registration data, 705 site-years of verbal autopsy data, 825 site-years of sample-based vital registration data, and 680 site-years of mortality surveillance data to estimate mortality due to tuberculosis among HIV-negative individuals. We used a population attributable fraction approach to estimate mortality related to HIV and tuberculosis coinfection. A compartmental meta-regression tool (DisMod-MR 2.1) was then used to synthesise all available data sources, including prevalence surveys, annual case notifications, population-based tuberculin surveys, and tuberculosis cause-specific mortality, to produce estimates of incidence, prevalence, and mortality that were internally consistent. We further estimated the fraction of tuberculosis mortality that is attributable to independent effects of risk factors, including smoking, alcohol use, and diabetes, for HIV-negative individuals. For individuals with HIV and tuberculosis coinfection, we assessed mortality attributable to HIV risk factors including unsafe sex, intimate partner violence (only estimated among females), and injection drug use. We present 95% uncertainty intervals for all estimates. Findings: Globally, in 2019, among HIV-negative individuals, there were 1·18 million (95% uncertainty interval 1·08–1·29) deaths due to tuberculosis and 8·50 million (7·45–9·73) incident cases of tuberculosis. Among HIV-positive individuals, there were 217 000 (153 000–279 000) deaths due to tuberculosis and 1·15 million (1·01–1·32) incident cases in 2019. More deaths and incident cases occurred in males than in females among HIV-negative individuals globally in 2019, with 342 000 (234 000–425 000) more deaths and 1·01 million (0·82–1·23) more incident cases in males than in females. Among HIV-positive individuals, 6250 (1820–11 400) more deaths and 81 100 (63 300–100 000) more incident cases occurred among females than among males in 2019. Age-standardised mortality rates among HIV-negative males were more than two times greater in 105 countries and age-standardised incidence rates were more than 1·5 times greater in 74 countries than among HIV-negative females in 2019. The fraction of global tuberculosis deaths among HIV-negative individuals attributable to alcohol use, smoking, and diabetes was 4·27 (3·69–5·02), 6·17 (5·48–7·02), and 1·17 (1·07–1·28) times higher, respectively, among males than among females in 2019. Among individuals with HIV and tuberculosis coinfection, the fraction of mortality attributable to injection drug use was 2·23 (2·03–2·44) times greater among males than females, whereas the fraction due to unsafe sex was 1·06 (1·05–1·08) times greater among females than males. Interpretation: As countries refine national tuberculosis programmes and strategies to end the tuberculosis epidemic, the excess burden experienced by males is important. Interventions are needed to actively communicate, especially to men, the importance of early diagnosis and treatment. These interventions should occur in parallel with efforts to minimise excess HIV burden among women in the highest HIV burden countries that are contributing to excess HIV and tuberculosis coinfection burden for females. Placing a focus on tuberculosis burden among HIV-negative males and HIV and tuberculosis coinfection among females might help to diminish the overall burden of tuberculosis. This strategy will be crucial in reaching both equity and burden targets outlined by global health milestones. Funding: Bill & Melinda Gates Foundation.
dc.language eng
dc.rights info:eu-repo/semantics/openAccess
dc.title Global, regional, and national sex differences in the global burden of tuberculosis by HIV status, 1990–2019: results from the Global Burden of Disease Study 2019
dc.type info:eu-repo/semantics/article


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